For the Aβ42/Aβ40 ratio, older adults showed a trend towards an interaction, F (1, 52) = 3.35, adjusted p = 0.05, η p 2 = 0.06, whereas younger adults showed no interaction effect, F (1, 52) = 0.02, adjusted p = 0.45, η p 2 < 0.001.
Although suggestive, our findings regarding the potentially clearance-related plasma Aβ42/Aβ40 and pTau-181/tTau ratios do not provide clear support that the interventions affected brain clearance as the Aβ42/Aβ40 changes did not quite achieve significance and there are other potential dynamics that could affect pTau-181/tTau ratios other than changes in brain clearance.