Barely Significant

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highly significantP < 0.00010.0× alphaqualifiedgold
Tadpoles in full water volume took on average 105.5 days (± 4.0 SE) to reach Gosner stage 38 and 132.65 days (± 4.25) to reach metamorphosis (Gosner stage 42), whereas tadpoles exposed to low water volume took 86.38 days (± 4.43) to reach stage 38 and 89.77 (± 4.0) days to reach metamorphosis, resulting in highly significant reductions in larval period ( F 1,44 = 23.20, P < 0.0001 for days to Gosner stage 38; F 1,45 = 40.91, P <0.0001 for days to Gosner stage 42) ( Figure 2A ).
highly significantp = 0.00010.0× alphaqualifiedgold
The effects of the study drugs on gut microbiome β-diversity at the OTU level were first tested statistically using a two-way NPMANOVA and the results revealed highly significant main effects for drug (F 4,65 = 3.35; p = 0.0001) and time (F 2,65 = 8.43, p = 0.0001), as well as a significant interaction (F 8,65 = 1.77, p = 0.0001).