Excerpts

Although cold tolerance is an abiotic trait, there may be significant crosstalk with biotic stress response or presence of gene families that act in both forms of stress response [ 74 , 75 ].

These results all indicate that despite a different definition of interaction and the potential loss of power due to overadjustment, many robust interaction signals remain highly significant.

Discussion Overall, these results demonstrate highly significant GIA activity against vaccine strain 3D7 parasites in the serum of children vaccinated with the FMP2.1/AS02A vaccine as compared to control rabies vaccine.

Both factors were found to be highly significant after being correlated using linear multiple regression at 95% confidence interval.

Since the less mature progenitors (CD34+KDR+CD133+) were significantly reduced only in severe COPD, while the CD34+KDR+ cells were highly significant even after adjustment, these findings support the hypothesis that CD34+KDR+ cells were being preferentially drawn from the circulation during mild and moderate COPD (increased utilization) and it is not until severe COPD that the more bone marrow derived cells (CD34+KDR+CD133+) become depleted (decreased supply).

Adjusted analysis showed a trend for increasing childhood vaccination with time.

This variable was marginally significant in the rural sample (aOR: 0.55, 95% CI 0.27, 1.17).

Soil particle-size distribution and fractal dimension In this study, land-use pattern was found to produce highly significant effects on the fractal dimensions of PSD, indicating that it is a primary factor influencing the PSD of alluvial fans in collapsing gullies.

Serum markers discriminate histological fibrosis stages All markers showed highly significant correlations with histological fibrosis stages ( S1 – S3 Figs).

When GWAS was performed a second time to include marker scores for rym4 and rym5 , only rym4 resulted in a highly significant association in both years (-log10( p ) values of 4.4 and 4.9 for 2009 and 2010 respectively).

While the average difference is modest, the p-value is highly significant because of large sample sizes.

HTN was associated with a decreased risk with borderline significance for peritonitis only on multivariate analysis of all HD patients.

Analysis of the rate of wound healing between Gα 11 KO/Gα q -WT control and Gα 11 KO/Gα q -eKO animals demonstrated a significant shift at all time points, leading to a highly significant difference in the wound healing curves ( Fig 4D ).

An increasing trend in precipitation, which is found for both models, can lessen or counteract a trend toward increasing dryness in SPEI.

A positive trend in precipitation can also dampen the increase in E 0 through the complementary relationship [ 89 , 90 ] by increasing available moisture, thereby impacting EDDI.

Five transplant sites showed a trend of higher LE of foreign corals and three sites exhibited a trend of higher LE of native corals, though none of these differences were significant ( Fig 3A ; Table B in S1 File ; S2 File ).

One-way analysis of variance and the least significant difference test were performed using the SPSS software (SPSS 13.0) package and * p < 0.05 and ** p <0.01 were considered to be significant and highly significant probability levels, respectively.

Conclusions This large population-based study demonstrates an association between GERD and future development of AMI, however, PPIs use only achieved marginal significance in reducing the occurrence of AMI in GERD patients.

The low eGFR was marginally significant.

Differences in choice of transport mode between college and non-college educated working young adults ( Table 3 ) The logit model showed a trend that, for cycling to work and for public transport to other destinations, being higher educated was associated with 47% lower odds of being a non-participant.

The B-B Score difference between the control and the patient groups was highly significant regardless of the device.

Our data point to an unexpected heterogeneity in the podoplanin-positive cardiac cell compartment, which might be significant for the processes of CLV growth after injury, development of fibrosis and scar maintenance.

While we were unable to demonstrate a statistical difference in prognosis, we did note an interesting trend toward shorter median survival in the HSC group when evaluating patients with all stages of disease.

MTX injection induced a highly significant increase in nuclear NF-κB p65 level in liver cells compared to control ( Fig 3IV ).

Multivariate cox regression analyses for prediction of survival showed a trend towards longer survival for higher values of the prediction score, but no significant association was demonstrated (PFS: HR 0.69 (95% CI: 0.40–1.19) p = 0.183; OS: 0.76 (95% CI: 0.42–1.40) p = 0.386), Table 5 .