The difference in excess observed similarity between the groups is highly significant (p<0.001, rank test), which suggests that amino acid identity is a poor measure for estimating physicochemical similarity, and thus T cell cross-reactivity.
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We observed a highly significant (p<0.001) reduction of ERα binding at all sites examined in RAD21-depleted MCF7 cells ( Figure 6A ), and a similar decrease in ERα binding at ERE 1 and the promoter region in T47D cells ( Figure 7 ).
Again, significant differences within the cohort were observed, with highly significant correlations between the C1 signature and PLAU/invasion module (p<0.001), the C2 signature and STAT1/immune response module (p<0.001), and the C4 signature and VEGF/angiogenesis module (p = 0.001).
The risk-adjusted multivariate Poisson regression model also indicated that patients' preferred location was a highly significant predictor for family global satisfaction (p = 0.001; Table 3 ).
When four additives with RNA and four without RNA content are combined together into two groups, differences between means of percentage of sa WT phenotype is highly significant (Kruskal-Wallis ANOVA, P <0.001).
These differences in response rates are highly significant (urban areas: χ 2 (1) = 49.470, p < 0.001; rural areas: χ 2 (1) = 23.837, p < 0.001).
The strength of inter- and intralimb coordination estimated with the length of vector r was highly significant ( p < 0.001) in all groups and attained values of 0.95–0.98 in intact rats, while saline and Riluzole treated rats showed ranges of 0.84–0.98 and 0.79–0.97, respectively.
Data are shown in mean ± SD (n = 4) and comparisons to the control (i.e., expression levels of non-stimulated cells) are marked as *** very highly significant (P<0.001), ** highly significant (P<0.01), or * significant (P<0.05).
One-way ANOSIM also revealed a highly significant effect of sampling site (Global test R = 0.797, P = 0.001) based on fish abundance data, represented a significant difference among the four group of those sites.
Heatmaps were constructed to enable visualization of data for the top 25 highly significant compounds that had large changes in abundance in dogs with sepsis at the lowest P-values <0.001 ( Fig 2C ).
Acoustic startle response measured in another cohort of mice (9 controls and 10 mutants aged 9 weeks) showed an altered curve: there was a highly significant interaction between genotype and startle pulse intensity (F (7,11) = 4.153, p<0.001), and Bonferroni posthoc tests revealed a significantly lower response of mutants at maximum dB (p<0.01, Fig. 2F ).
For the P 135 condition there was a highly significant effect of position ( F (1, 9) = 38.898; p < .001), with the orientation discrimination test threshold at the trained position ( Fig 3B , black circle) being lower than the average threshold of all other test positions ( Fig 3B , black square).
The analysis generated four discriminant functions which revealed a highly significant difference between call types (Wilks' λ DF1/4 = 0.002, χ 2 = 2446.73, p<0.001; Wilks' λ DF2/4 = 0.088, χ 2 = 934.53, p<0.001; Wilks' DFλ 3/4 = 0.519, χ 2 = 252.48, p<0.001; Wilks' λ DF4 = 0.985, χ 2 = 5.93, p<0.05).
In these two cases, the variation in transmission bias is supported by highly significant heterogeneity G -tests (multilocus genotype 45: G = 32.750, P <0.001; multilocus genotype 58: G = 27.534, P = 0.001).
As the univariate treatment effects in all models remained highly significant (P<0.001) until 20 DPP ( Table 4 ), only contrasts taking place on or after 15 DPP were considered.
The association between overall mortality and increasing age remained highly significant when adjusted for underlying co-morbidities or immunosuppression (p = 0.001).
The prototypicality of rationality for morality scale came out as a highly significant predictor, β = .54, t (179) = 7.86, p < .001.
Our two pairs were marginally significantly different from each other (wald = 9.73, P = 0.08) while lakes and streams were clearly significantly different in MHC allele composition (wald = 15.5, P<0.001).
A decreasing trend of HAV notification rate over the years was identified (p<0.001).
We observed marginal (r>0.6) but highly significant (p<0.001) correlation between SPA and cytokines such as IL-6, PDBF-BB and duration of symptom.
We found highly significant increases of pABG (p≤0.001, Figure 4C ) and apABG concentrations in spot urine (p≤0.001, Figure 4D ) from baseline with habitual folate intake to week 6 and week 12 of supplementation in subjects supplementing 400 μg folic acid per day in addition.
The result indicated that there was statistically highly significant difference in egg-laying inhibition effect (p < 0.001).
During the 6 years of anthelmintic treatment, differences between baiting and control areas were highly significant ( P <0.001).
Although the association of eGFR with LDL-C lost significance after further adjustment, the associations of eGFR with apoC-III remained highly significant in the fully adjusted model that also accounts for urinary ACR (p = 0.001).
A Fisher’s exact test confirmed a highly significant association between stimulus type and sentence production ( p < .001, OR = 143.75), demonstrating that the target stimuli successfully and reliably elicited subjective motion sentences compared to controls.