Excerpts

(Of note, the EMN estimation was repeated across different p value thresholds [i.e., defined as the limit of the top 0.5% p values and top 0.3%], obtaining consistent results across all thresholds, with strong highly significant correlations with the original EMN values [all r ~ 0.84, p < 10 −30 ].) Next, taking the 7718 values as data, we used a novel contrastive trajectories inference (cTI) algorithm to aggregate the DNAm data by identifying the trajectories of individuals aligned/ordered with the severity of epigenetic alterations hypothetically associated with maternal neglect.

Thus, we used HOMER analysis for known motifs, revealing highly significant consensus motifs such as NRF1 ( P = 10 −30 ) and ZBTB33 ( P = 10 −24 ) ( Fig S6A ).

In two-way (genotype and environment) ANOVA, the genotypic variations for the four index traits were highly significant ( P -value = 8.57e-29 ~ 3.62e-11) (Table S3 ), indicating the feasibility of conducting GWAS for the four index traits.

The type of incubation fluid exhibits a highly significant impact on the sorption ability, as indicated by an exceptionally low p -value ( p = 2.45 × 10 −28 ), suggesting that the fluid type strongly influences the swelling behavior of hydrogels.

However, although the difference in terms of percent variation explained in RBC by SSCCA vs SSMCCA methylomics CV1 is highly significant (p-value = 3E-28), the absolute difference (4.27E-8 percent variance explained) is tiny, suggesting the difference between the performance of two methods is negligible.

Although the MHC association is highly significant in both OLP and non-OLP, it is dramatically stronger in non-OLP ( p = 5.6 × 10 −28 for difference in effect), and the association in non-OLP near CLEC16A does not even reach nominal significance in OLP.

The discrimination capacity of the model was high (AUC = 0.811) and highly significant ( p = 1.782 × 10 –27 ).

The samples clustered into two distinct and well-separated classes, and evaluation of the model showed that it was highly significant ( p = 2.3E −27 permutations p = <0.001).

S3A), but the overall altered profile was highly significant ( P = 10 −26 , Fisher exact test in comparison with the ∼8,000 genes expressed).

The test revealed a highly significant discrepancy between Google Gemini and the registrar (p = 1.13 × 10 -26 ).

Indeed, 26% (133 out of 508) of differentially expressed proteins from Cd2ap +/− heterozygotes were also seen in Cd2ap −/− homozygotes, comprising a highly significant overlap ( P = 1.6 × 10 −26 ) ( Fig. 7A ).

The correlation between “correlation coefficients of gene expression levels with reexperiencing symptoms in patients” and “fold change (FC) after retrieval in mice” for the 413 genes was highly significant ( r = 0.49, p = 7.3E-26) (Fig. 3D ).

Of note, a recent study reporting a highly significant genetic correlation between endometriosis and migraine (r g =0.38, p=2.30×10 -25 ) also implicated TRIM32 as an overlapping gene between the two disorders. 37 The role of TRIM32 as a potential risk variant in migraine, CTS, and endometriosis is yet unclear and requires further study, though it is intriguing to note its association with three disorders that predominantly affect females. 38 – 40 The notion of migraine as a peripheral nerve disorder remains debatable, as it conflicts with longstanding theories of central generation of migraine.

The results were highly significant: p = 1.11 × 10 −23 ( Fig 3A ); p = 5.29 × 10 −16 ( Fig 3B ); p = 3.88 × 10 −5 ( Fig 3D ); p = 1.38 × 10 −16 ( Fig 3E ); p = 1.00 × 10 −9 ( Fig 3F ).

47 The most recent GWAS for JT and QT intervals found highly significant associations, respectively, with rs17171731 ( P = 4E-23) and rs1335516 ( P = 1E-43, in very high LD with each other in European ancestry populations), with the AF risk allele associated with longer durations. 48 The GTEx project shows relatively low expression of FAM13B in human left ventricle (median value 5.5 transcripts per million), and no significant left ventricle FAM13B eQTLs are detected.

Previous reports have implicated deleterious coding variants in IFIH1 , the third member of the RLR family, as conferring protection against psoriasis 8 , 71 and psoriatic arthritis 72 ; the protective IFIH1 variants rs35667974 and rs1990760 are both highly significant in the current meta-analysis ( P = 5.0 × 10 −23 and 7.0 × 10 −50 , respectively) but not prioritised in credible sets due to insufficient effective sample size and the presence of a more strongly associated intronic variant (rs2111485), respectively.

S3), as well as a highly significant negative genetic correlation between c-intensity and age at menarche (rg = − 0.52, P = 6.72 × 10 −23 ), indicating that genetic determinants of later pubertal onset also favor a slower tempo of growth.

Survival analysis confirmed the highly significant impact of IL-6 (P = 8.56e−23) on the survival of COVID-19 patients and also identified a nominally significant effect of IL-2R on survival (P = 0.0003, Figure S1 , Table S1 ).

Moreover, as anticipated, differences between the mean pH values of the n = 6 participants included in this phase of the study were indeed very highly significant ( p = 9.42 × 10 −23 ), with ranges in their mean values being 5.49–6.37.

The DML overlap between the two cohorts was highly significant ( p = 1.71 × 10 −22 , 8.17 × 10 −33 and 3.13 × 10 −44 in B cell, memory T cell and Naïve T cells, respectively, by hypergeometric tests).

Educational Resources also presented a highly significant effect ( p = 2.8 × 10 −22 ), with a moderate degree of association between categories ( φ c = 0.439), and the same was true for ESAR Facets ( p = 5.15 × 10 −16 ; φ c = 0.366).

Consistent with this hypothesis, there was a moderately strong, but highly significant, correlation (Spearman rank correlation = 0.47, p < 7.2 x 10 −22 , S5 Fig ) between the ConSurf score for a residue and the median yeast assay score for substitutions at that site, with more conserved residues displaying lower median growth.

The median follow-up for T-DXd was 16.2 months; the median PFS was 6.8 months for the T-DM1 groups, while the median PFS had not been reached for the T-DXd group, with a highly significant difference (HR of 0.28, 0.22-0.37, P = 7.8 × 10 -22 ).

In terms of correlation analysis, the Pearson correlation coefficient was 0.959, demonstrating a very strong positive correlation between ADRRPs and phoropter measurements ( p = 8.13 × 10 − 22 , highly significant), while the Spearman correlation coefficient was 0.878, also indicating a strong positive correlation ( p = 2.03 × 10 − 1 3 , highly significant).

This SNP was also highly significant in our analysis ( p = 5.4 × 10 −21 , beta = 0.27 years, effective-allele = G).