Barely Significant

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highly significantp < 0.0010.0× alphaqualifiedgold
The sex difference in directional discordance also persisted and remained highly significant (χ 2 (2) = 29.784, p < 0.001): among females, lower-than-tertile 48.5%, matching 39.4%, higher-than-tertile 12.1%; among males, lower-than-tertile 27.2%, matching 37.0%, higher-than-tertile 35.9%.
an increasing trendP <0.0010.0× alphagold
Comorbidities and vascular complications Between 2010 and 2020, the prevalence rates of hypertension, dyslipidemia, and fatty liver disease in young adults with T2DM showed an increasing trend, reaching 34.2%, 79.8%, and 78.9%, respectively, by 2020 ( P <0.001 for all) ( Fig. 4A , Supplementary Table 5 ).
highly significantp < 0.0010.0× alphaqualifiedgold
Results: Multivariable GEE analysis demonstrated that the Systemic Immune-Inflammation Index (SII) was a highly significant independent risk factor (OR for a 500-unit increase = 1.490, 95% CI: 1.234–1.798, p < 0.001).
highly significantP <.0010.0× alphaqualifiedgold
The profound and consistent intermodel differences, confirmed by highly significant Friedman tests ( Table 3 ; all P <.001) and detailed in the pairwise comparison heatmap ( Figure 3 ), underscore that these performance characteristics are inherent to model architecture and training, not artifacts of query phrasing.