Excerpts

This result is highly significant, with P-value<10 −77 ; this p-value is calculated based on 10,000-time permutation evaluating the possibility that 66 out of 83 randomly selected regions overlap or contain with CpG island.

As additional validation supporting the role of myeloid-derived cells, and specifically monocytes, as a dominant contributor to plasma CyC levels, we found a significant positive correlation between blood monocyte counts and CyC residual in the UKB cohort ( Figure S4 B; multivariate regression), and two-sample Mendelian randomization using blood-derived CST3 eQTLs (eQTLGen 58 ) as exposure identified a highly significant positive association with CyC production (p = 6.13e−77; Figure 4 E).

Results for the theta band showed a highly significant association between the mean relevance of each brain region, and how their centrality changes in association with p-tau231 levels (rho = 0.499; p = 9.2 × 10 –77 ).

Similarly, the results revealed a strong positive correlation between RA Factor and disease severity, with Spearman’s ρ = 0.902 and a highly significant P -value < 3.9 × 10 −76 ).

All genome-wide analysis was conducted with only highly significant enhancers [-log10(P) > 75] and NREs [-log10(P) > 30] which intersected strongly accessible chromatin from peaks which overlap MACS peaks called from the input plasmid library alone.

The Pearson correlation of individual question scores for the same participant was r = 0.19, which was highly significant with p = 7e-75 (n = 9520).

We performed reduced representation bisulfite sequencing (RRBS), 5 a technology for interrogating hundreds of thousands of methylation sites with digital precision 27 , 28 on the rat PNS and found characteristic and highly significant patterns relating gene methylation and activity (p≈1.0x10 −74 ) that differed markedly between LCP and HCP genes.

The results clearly show an overall highly significant increase in the number of such events in TA MSI clones compared to TA MSS malignant clones ( p -value < 2 × 10 −74 ).

T2D status was found to be a highly significant predictor of weight loss efficacy ( P = 2.0 × 10 −73 ; Supplementary Table 4 ), with an average predicted reduction of 2.87 percentage points in BMI loss for people with a T2D diagnosis.

The test was highly significant ( p = 6.77 × 10 −72 ), indicating that the data were not missing completely at random (MCAR).

3 B and D) showed a trend of gradually transforming from multimodal to bimodal (core–satellite mode) — the “middle sector” of species with P = 30–70% gradually disappeared from the communities.

Lola-N binds to 1,369 genes (false discovery rate [FDR] < 0.1%) that show a highly significant overlap (p < 6 × 10 −71 ) with the 836 genes (FDR < 0.1%) bound by Prospero.

However, the effect of sex is highly significant ( p = 2.62 × 10 −70 ).

A highly significant statistical analysis ( p = 1.14×10 −69 ), also in agreement with its experimental counterpart, further supported the evidence for gradient directed migration of the MV3 melanoma cells inside the virtual chamber.

In the GSE14520 cohort, risk scores showed a trending stage-dependent increase from nontumor tissues to early-stage HCC (BCLC 0/A) and more advanced HCC stages (BCLC B–C), with highly significant differences across all groups (overall p =1.86×10 −69 ; Fig. 5A ).

The overlaps with plasma were 47 (T1∩plasma) and 54 (M1∩plasma), both highly significant after Bonferroni correction (Fisher’s exact test p < 10−68 and p < 10−74; Supplementary Fig. 2a ), supporting the reliability of the plasma-derived ground truth.

This difference is highly significant ( t -test, P = 2.15 × 10 − 68 ).

The regression model including these four significant factors was moderately predictive of matrix-like volume (R 2 = 0.32) but highly significant (F (7, 844) = 57.8, p = 1.2 × 10 –67 ).

A scatter plot of gene significance (GS) against module membership (MM) for genes in the blue module indicated a highly significant positive correlation (correlation coefficient = 0.77, P =9.2×10 −67 ; Figure 2D ), implying that these genes may play central roles in ferroptosis regulation.

The obtained test statistic demonstrated a highly significant variation among algorithms (χ2 = 361.47, df = 17, p = 2.02 × 10 − 66), confirming that the null hypothesis of equivalent performance can be rejected at the 0.05 significance level.

Of the signs and symptoms, 269 were significantly enriched in specific diagnoses, of which 148 were also a priori defined to be of diagnostic importance, a highly significant enrichment (χ 2 = 295.96, P = 2.5 × 10 −66 ).

Of the 9555 SRF regions from Triform, 124 regions overlapped with MER57 repeats (with an average overlap of 91%), and 117 of these contained at least two significant binding sites for TFs (from the CisFinder analysis), which is highly significant ( p = 1.2 × 10 -65 according to a Fisher exact test).

Gene ontology (GO) enrichment analysis displayed a highly significant over-representation of the “RNA-binding” molecular function category (GO:0003723), with an enrichment score of 147.76, p = 6.77 × 10 −65 , and FDR step up = 1.47 × 10 −60 for 6A1, and an enrichment score of 98.44, p = 1.77 × 10 −43 , and FDR step up = 3.84 × 10 −39 for clone 3B2 ( Figure 6 ).

The overlap between CS = 0 and CS = 1 was small but significantly non-random (Table 1 , chi-square, P = 1.2 × 10 -64 ).

COL6A3, COL1A1, COL3A1, THBS2, COL5A1, and LAMC1 all exhibited significant upregulation with highly significant p-values (e.g., COL6A3, p = 2.89 e-64 ; COL1A1, p = 9.21 e-90 ) ( Figure 7A ).