Excerpts

The difference in the slopes between the Braf wild type and mutant mucosal samples was highly significant ( P <0.0001), reflecting the temporal accumulation of DNA methylation events following induction of the Braf mutation.

However, there was a highly significant 20 fold increase (P = 0.0001) from 5 to 7 dpi (4,291±1,172 ng/ml).

In each subject the proportion of variance explained was superior in the non-shuffled data and this difference was highly significant (Wilcoxon signed rank test, all p values <.0001).

Nevertheless, non-parametric Spearman correlation analysis of all 96 data points demonstrated highly significant ( P < 0.0001) positive correlation between the DPPH and FRAP results ( R = 0.852).

Figure 1 shows a decreasing trend with time for SBP, which was confirmed by a repeated measure ANOVA analysis (F(1,198) = 394.4, p < 0.0001).

The average decrease in fat mass was highly significant ( P < 0.0001), as were decreases in percent body fat and body mass index.

A highly significant positive correlation ( ρ = 0.95, P < 0.0001) between expression levels and the normalized difference between ω mus and ω cas ( δ ω ) provides confirmatory support for our results ( fig. 3 B ).

This pattern was also true of the linear trend where this level of association was particularly apparent in relation to the high intensity angry expressions, such that the mean number of FRAXE repeats showed a trend - the more FRAXE repeats, the more likely was the boy to recognise extreme anger (P<0.0001).

An objective validation of the self-reported smoking history of a randomly selected sub-sample immigrant group, using expired carbon monoxide (CO) measurements, showed a highly significant correlation coefficient (r = 0.64) of expired CO levels with the reported number of cigarettes consumed (p < 0.0001).

Enzyme activity in the male group was significantly lower than in the female group, with an extremely significant decrease ( p < 0.0001).

Curd and curd with red chilli powder had a significant association with the development of CRC with an OR of 2.7280 (95% CI 1.6346 to 4.5531) and 5.0806 (95% CI 2.4015 to 10.7485), respectively, which was highly significant (p < 0.0001).

However, due to the extensive variance in fingertip force between the participants across all 13 stimuli, the explained variance was small while still highly significant ( R2 = .062, F (1,257) = 8.49; p < .0001).

Although differentiation among subgroups was highly significant (P<0.0001), 76.95% of total genetic variance was attributed to the difference within subgroups and 1.51% within individuals.

In contrast, compared to α IIb β 3 , both α v β 3 and α 5 β 1 reveal a highly significant reduction of overall contacts by ~10% ( p < 0.0001) (Fig.

These differences in allele distribution were statistically highly significant (χ 2 = 75.945, df = 2, p < 0.0001), which confirms a strong association between APOE allele status and disease status.

Statistical analysis using the Student’s t -test for related samples showed a highly significant difference between pre- and post-test scores ( p < 0.0001), indicating a strong effect of the intervention on stress reduction.

The difference between the average tumor growth rates in the treated and untreated groups was highly significant ( P <0.0001).

Differences between strains were highly significant by one-way ANOVA with Tukey’s multiple comparisons test (F(3, 8) = 299.2, p < 0.0001).

As shown in Table 4 , the model exhibited highly significant differences ( p < 0.0001), with the lack-of-fit term yielding a p of 0.3237 (>0.05).

The difference in GERD-HRQL before and after RAP was highly significant (absolute reduction 22.3, P < 0.0001, 95 % CI 19.3 – 25.3).

The spline for child age was highly significant ( χ 2 = 459.23, df = 8, p < 0.0001) and showed a more complex functional form (EDF = 6.95).

The results revealed a highly significant correlation between the MRP and N-myc expression (r=0.795, P<0.0001), and no involvement of the expression of these genes in the prognosis of the patient.

The agreement between the expected and estimated connective field locations shown in Figure 2 a (diagonal cells in the connectivity matrix) is further demonstrated by a highly significant mean (across subjects) Cohen's kappa value (M = 0.68, S.D. = 0.2, t 11 = 12.0, P < 0.0001).

In our study, we observed a highly significant increase ( Table 2 : p ≤ 0.0001; FC = +8.187) in hypoxanthine excretion in all 20 cases studies, which peaked at one hour after alcohol consumption in 18 of the cases, and at 2 hours in the other two cases ( Fig 4E ).

Treatment had a highly significant effect on disease control (F(3,8) = 1553, p < 0.0001, R 2 = 0.9983).