This ~10-fold reduction in mean numbers of foci with respect to the WT is highly significant (unpaired t-test; p < 0.0001) and confirms the SPO11-dependence of the great majority of the observed pachytene EdU foci.
Excerpts
Among the two hiPSC lines, the highly significant ( P < 0.0001, paired t test with Bonferroni correction) reductions in methylation observed for the donor L1 during hiPSC derivation (25.0% on average) far exceeded that seen for the lineage progenitor (12.5%) and L1-Ta subfamily (2.9%) ( Fig. 5C and 6B ).
When the usage of digital media for studies, social media and/or entertainment, games and following the news was combined, multivariate nominal logistic regression identified four highly significant explanatory variables for digital media usage among adolescents in Bissau ( R 2 = 0.0409, p < 0.0001), which were gender (boy, OR 2.18, 95% CI 1.64–2.88; p < 0.0001), attending a private school (OR 1.57, 95% CI 1.17–2.88; p = 0.0027), being born in Bissau (OR 1.45, 95% CI 1.09–1.94; p = 0.0107), and coming from a family that could afford to buy a car (OR 1.33, 95% CI 1.00–1.77; p = 0.0478). 3.5.
The prevalence of ocular morbidities was found to have highly significant association with the educational status of both the father ( P = 0.0001) and mother ( P = 0.001).
It is noteworthy that all the 64 MDR cases were exclusively found among the retreated patients, bringing the proportion of MDR isolates in this group to 77.1% the difference of drug resistance between new versus retreated cases being highly significant ( P value < 0.0001).
The distribution of response categories differed significantly across timepoints (χ2 p <0.001), with pairwise significance between 1 and 2 months ( p = 0.034), and highly significant differences between 1 vs. 3 months and 2 vs. 3 months (both p <0.0001).
However, a χ 2 test for any versus no rainfall for case and non-case locations was highly significant ( P < 0.0001) for this time period.
The mean baseline level of 25(OH)D was 9.59 ± 7.59 ng/mL, and after 6 weeks 19.51 ± 4.27 ng/mL, mean increase being 9.99 ± 6.83 ng/mL, which was highly significant ( P < 0.0001).
Similarly, GTR conferred a highly significant survival advantage ( p < 0.0001), underscoring the importance of maximal safe cytoreduction even in real-world cohorts with high resection rates (88.4%).
Tumor-free samples and tumor-bearing samples showed clearly significantly different values ( p < 0.0001 each) for all 3 parameters (weight, tracer uptake, SUL).
Chi square values for the independence between genotypes of RM136 and days to heading (early and late heading divided by the dotted line in Figure 1 ) were 26.880, 81.073, and 86.693 for Jpn1, Jpn2, and W1297, respectively, all highly significant ( P < 0.0001).
These findings are statistically highly significant (group A vs. group B: p < 0.0001) ( Table 4 ).
As shown in Figure 6B , a highly significant difference in OS was detected between the high- and low-risk groups ( P < 0.0001).
2 a), and differences among feeding groups were highly significant (ANOVA F 7, 88 = 292, P < 0.0001 for FB NY ; F 6, 54 = 204, P < 0.0001 for MC SC ).
Results Analysis of Phenotypic Variation for Disease Severity at Seedling Stage The ANOVA results revealed highly significant variation ( P < 0.0001) for germplasm lines and pathotypes ( Table 1 ) while the genotype × year interaction effect was found to be non-significant.
Not surprisingly, two-way ANOVA showed that both NK1 concentration and injection number were highly significant ( p < 1 × 10 −4 ).
5 ) compared with patients in the control group was also highly significant (44.0% vs. 7.4%, P < 0.0001).
The linear regressions between the available energy and the measured energy fluxes were all highly significant ( P < 0.0001).
For the 170 workers with measured TCDD levels greater than 10 ppt, the Spearman correlation between their cumulative exposure scores and the back- extrapolated lipid levels was highly significant (rho = 0.65, p = 0.0001).
Statistical analysis confirmed highly significant differences in the levels of neutrophils, RBCs, PCV, Hb, MCH, urea, creatinine, total protein, albumin, globulin, A/G ratio, and PCT ( p < 0.0001 for each), as well as CRP ( p = 0.002), among infections caused by PDR, XDR, and MDR isolates.
Both LPO substrates mediated A/California/04/2009 viral inactivation beyond detection limit of the assay in the cell-free system which was highly significant (p<0.0001, for each substrate) ( Fig 3A ).
When micro CT was compared with all the other techniques in analyzing the racial predilection of C-shaped canal configuration, it showed a statistically highly significant result with P < 0.0001 except when compared with CBCT which showed a significant value of P = 0.0303 [ Table 4 ].
The difference in the least square means of the total score was −8.01 (95% CI: –10.70 to −5.31), with a highly significant difference in favor of mannitol ( p < 0.0001).
Focusing on MCC of the skin ( N = 19,020), the overall proportion of MCC among skin cancers showed an increasing trend over the years ( P < .0001).
A primary finding is the highly significant coordination between thorn density and thorn angle ( p < 0.0001).