In the control group there was a barely detectable statistically significant difference in mean IMR ( F (2–16) = 3.897, p = 0.042), and the Bonferroni post hoc test did not reveal significant difference between time points.
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“a barely detectable statistically significant difference”
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p=0.073
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General Characteristics of MBC and NSIBC There was a barely detectable statistically significant difference in the site of the lesion between the two groups (64.71% vs. 48.27%, P =0.065).
At multivariate analysis, after adjusting for stage, LDH, PS, treatment received (BRAFi+MEKi vs BRAFi), subsequent immunotherapy (yes/no), metastatic MPs with high intratumoral, but not peritumoral, CD8 + T cells density showed a barely detectable statistically significant difference in terms of OS (HR 0.65, 95% CI 0.41–1.04, p = 0.072) (Fig. 4 ).
The AUC of APOSF-nomogram for predicting advanced fibrosis was 0.845 (95 % confidence interval [CI]: 0.754–0.936) in the development set which was significantly better than APRI (0.714, 95%CI: 0.598–0.830, P = 0.011) and a barely detectable statistically significant difference was found compared with FIB-4 (0.768, 95%CI: 0.651–0.884, P = 0.073).
The overall stability as predicted by the FoldX algorithm [ 32 ] was higher in oscillating proteins when compared to non-oscillating proteins (although with a barely detectable statistically significant difference), whereas the terms represented by interresidue Van der Waals’ clashes and electrostatic interaction ( Table S8 ) between molecules in the precomplex were significantly different.