“a notable trend”

Discussion Glucose and lipid metabolism disorders have become a common public health problem, with a notable trend toward affecting younger populations [ 33 , 34 ].

17 , 29 , 30 In our study, we observed a notable trend of higher PLRs being associated with a higher likelihood of being a late responder to omalizumab treatment.

36 Our study reveals a notable trend: the probability of BDZ use as the first line of treatment is higher when administered outside the hospital by EMS personnel.

The results that are of borderline statistical significance indicate a notable trend but possibly reflect the limited sample size.

Results The first case study, spanning the 16th–20th centuries across three sub-periods, reveals a notable trend of settlement abandonment and colonization of new areas (Table 1 ).

An interaction analysis confirmed no significant differences between the ICU and non-ICU groups in either level or slope changes for both outcomes, suggesting that the intervention’s effect was similar across settings, despite a notable trend toward reduction within the ICU group.

Furthermore, we observed a notable trend in the limited subset of patients receiving RC48 in combination with chemotherapy.

On the 3‐month MRI, we found a notable trend toward lower DKI metrics, MK and RK in the internal capsule in patients with PCS when compared with those without PCS and healthy controls.

As the isothermal crystallization temperature increases, a notable trend emerges across all composites: the crystallization peak progressively shifts to longer times, and the peak broadens.

23 However, we observed a notable trend toward a higher frequency of these mutations in the AITL-MN cohort compared to the MN-AITL cohort.

A notable trend is that aggregates with a single positive charge, i. e., systems with one more Li + than TFSI − , tend to contribute to the components at higher Raman shifts (see the discussion of Figure S5 in the SI).

A notable trend is the sharp decline in the number of mature eels in the Yangtze River, largely due to overfishing and environmental changes [ 48 ].

Exercise and MT and their influence on cytokines There was a notable trend toward an increase in pro-inflammatory cytokine levels with acute exercise, and a reduction in cytokine levels with longer-term, chronic exercise ( 51 , 55 , 60 , 63 , 83 – 90 ).

In our study, the LSR group exhibited a notable trend: 18 procedures were adeptly completed by a single surgeon, with only two instances requiring the assistance of a second operator due to intraoperative bleeding.

From 2018 until 2022, a notable trend shows an increase in malaria cases during the second half of each year.

The occurrence of DAT has been subject to numerous investigations worldwide, revealing a notable trend of increasing frequency.

In contrast, species described from 1971 to 2024 demonstrate a notable trend, with the majority of described species being validated.

The physical and chemical properties of mango rhizosphere soil with different diseases were examined, most of the physical and chemical parameters of TN3 showed marked differences when compared to TN2 and TN1, with a notable trend of increase as the severity of disease escalated.

Our analysis revealed that among the study population of patients with MI, the largest proportion of patients was classified as having CKM Stage 4, with a notable trend of increasing age in more advanced CKM stages.

Conclusion In PDAC, the prevalence of TyG-high status exhibits a notable trend: it is higher in the early stages of the disease and diminishes in advanced stages.

Although the role of neutrophils in CLL has traditionally been underestimated, recent studies have brought attention to a notable trend: CLL patients exhibit a higher inclination for NETs release compared to their healthy counterparts.

However, with an incremental cobalt loading in the Co/Al-SBA-15 series, a notable trend emerges, the strong acid content gradually diminishes, while the medium acid content rises.

SARS-CoV-2 infection during pregnancy is associated with placental iron deposition and lipid peroxidation Compared with SARS-CoV-2− controls, placentas from SARS-CoV-2+ cases showed a notable trend toward elevated iron accumulation with a moderate effect size (Cohen’s d = 0.52) ( Figure 1 A,B) and no significant changes in 4-HNE levels ( Figure 1 D,E), a marker of lipid peroxidation.

A notable trend observed across all models is the higher achievement in P metrics compared to R.

Observational studies conducted in real-world settings revealed a notable trend towards a reduced fracture risk associated with GLP-1ra, or DPP-4i utilization, although this relation didn’t statistically significant ( 28 ).