By contrast, prompted by a worrying trend in one of two trials of combination antiretroviral therapy in HIV/AIDS, the two DMCs agreed to share key outcome data on the basis of strict confidentiality, and the resulting analysis provided the reassurance needed to allow continued recruitment [ 13 ].
A worrying trend, however, is that despite the magnitude of the rise in 25(OH)D testing this did not translate into increased testing for physiological endpoints associated with 25(OH)D deficiency, such as osteoporosis. 23 24 over the long term. 25 Our data showing marked variation in the frequency of testing in individuals further support calls for the adoption of more specific 25(OH)D testing guidelines internationally and in Australia.
Although tigecycline resistance has not been tested at the time of isolation (Leski et al., 2013 ), the high frequency of tet (X) encountered in clinical samples signifies a worrying trend.
Reports from West Africa indicate a worrying trend of dyslipidaemia among patients with either type 1 or type 2 diabetes mellitus. 36 Data from the Transition of Health during Urbanisation of South Africa (THUSA) study indicate that black South Africans may be protected from IHD because of favourable lipid profiles characterised by low total choles
A worrying trend is that the high prevalence of childhood obesity in most Pacific Island communities [ 9 , 10 ] has more than doubled [ 11 ].
More importantly, though, there is a worrying trend: patients with BD have fewer friends both in real-world settings and on the Internet, and their online behavior (in terms of frequency and knowledge of terms used in SNS) does not match that of healthy individuals in the same age group.
A worrying trend indicates that 90% of new infections in children are due to mother-to-child transmission (MTCT).
in 2030), the number of PD sufferers is projected to increase to close to 10 million, which is clearly a worrying trend.
If a worrying trend of an increased fall risk would occur as a result of the treatment, therapists are expected to adapt their treatment accordingly and report this to the safety board of the trial.
These changes over a relatively short time-span (6–18 years) across many sites is a worrying trend, particularly because most of these sites were only moderately disturbed by humans at the outset of the study ( Fig. 6 ).
This is the first report of bla CTX-M-15 in UK river waters and represents a worrying trend as this gene is the most common ESBL in E. coli and Klebsiella spp . causing clinical disease. 4 Novel hosts were isolated across the Gammaproteobacteria, including Citrobacter braakii , A. media and P. fluorescens , none of which has previously been reported as a carrier of bla CTX-M-15 .
However, a worrying trend is emerging whereby Wolbachia infections have been demonstrated to enhance rather than suppress pathogens in some systems [12] – [18] .
baumannii and a worrying trend of antimicrobial resistance in the ICU of the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam.
If such risk factors are becoming more common in SSA as a whole, then this is a worrying trend.
High prevalence of obesity in school going children is a worrying trend and portends of future increase in obesity related diseases.
A worrying trend is the increased prevalence of non-nucleoside RT inhibitor (NNRTI) related mutations in newly diagnosed patients [ 3 , 5 ], as single NNRTI mutations, such as the frequently observed K103N mutation, can result in high levels of resistance against first generation NNRTIs [ 6 ].
However, it is difficult (and unrewarding) to publish the results of replicative experiments or negative data, and there is a worrying trend in the lack of reproducibility in some forms of analysis; this issue was recently highlighted with regard to the widely-used technique of fluorescence-activated cell sorting ( Hines et al. , 2014 ).
The National Health and Morbidity Surveys (NHMS) thus far have focused on the major ethnic groups of Malay, Chinese and Indians, which displayed a worrying trend of increased diabetes prevalence from 6 · 3% in 1986 to 14 · 9% in 2006 [ 12 - 14 ].
The African countries show a more mixed tendency, but there is a worrying trend of an increasing consumption in several low- and middle-income countries in South-East Asia and the Pacific Region, most likely as a result of the economic development [ 13 , 21 ].
Background Escalating reports of treatment failure and emergence of resistance worldwide with the use of standard short course chemotherapy for tuberculosis (TB) reflect a worrying trend.
Discussion In recent years we have observed a worrying trend of increased occurrence of OSCC in young Zambian adults.
While tobacco and alcohol are recognized as being primary etiologic factors for oral squamous carcinogenesis, there is a worrying trend in the incidence of oral cancer in patients who have never used these agents ( 97 ), raising the possibility that other factors may have a major role in tumor progression in these subjects.
A worrying trend of frequent consumption of non-alcoholic fizzy drinks was found in 2/3 of the children.
Furthermore, in a recent meta-analysis, in the subgroup of women with a cervical length of >25 mm treated with 17-OHPC there was a worrying trend towards increased adverse perinatal outcome (RR 2.1, 95% CI 1.9–2.2) [ 30 ].
Charlton, M.D., from the University of Newcastle upon Tyne, who in 1996 in the Journal of the Royal College of Physicians in London , summed up the state of population-based epidemiology: There is a worrying trend in academic medicine which equates statistics with science, and sophistication in quantitative procedure with research excellence.