Barely Significant
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almost statistically significant

4 sentences · 4 papers · 391 search hits before verification · confirmed specimen

Sighted at

p=0.06

Listed by Hankins (2013) · Otte et al. (2022)

In the literature

These results do not allow us to assume that RB1 HD are a priori less sensitive to ICIs than the other RB1 mutants, as the RB1 HD have a higher (and almost statistically significant) average TMB and a significantly higher neoantigen load than the rest of the RB1 mutants as a whole, even though RB1 HD also have a lower relative infiltration of immunity relevant cell populations and their signaling (cytotoxic lymphocytes, NK cells, B cells, the monocytic lineage, the T cell inflamed signature and the cytolysis signature) than the rest of RB1 mutants when they are both compared separately with RB1 WT samples (please see the first section of the Results).