“an increasing trend”

The percentage of appropriate prescriptions per month showed a different trend between physicians and non-physicians (Table 2 ); in particular, an increasing trend was observed in physicians (β = 0.07, SE: 0.01, 95%CI: 0.04; 0.10, p < 0.001), while a significant decrease was observed in non-physicians (β = -0.13, SE: 0.05, 95%CI: -0.23;-0.03; p = 0.013).

Generally, we found an increasing trend concerning crude seropositivity with advancing age ( p < 0.001); however, differences were only significant when comparing the older age group 60–69 (5.2%; 95% confidence interval (CI) 4.5–5.9%) to the younger age group 20–29 (2.6%; 95%-CI 1.8–3.5%) (Table 1 ).

A total of 955 cases of pathogen positive were reported, showing an increasing trend year by year ( χ 2 trend = 59.773, p < 0.001).

Within-group comparisons revealed a decreasing trend in fatigue scores over time for the FM and BB groups, while the control group showed an increasing trend ( p < 0.001) (Table 3 ).

The odds of GDM had an increasing trend according to the BMI (p < 0.001).

Custom interval analyses further demonstrated a declining trend before the pandemic (1999–2019; AAPC=-0.2709%, 95% CI:-0.4281 to -0.1087, P < .001) and an increasing trend during the pandemic period (2020–2024; AAPC=1.2879%, 95% CI: 0.9922 to 1.6558, P < .001).

In terms of annual prevalence, the prevalence of total CHDs showed an increasing trend ( P < 0.001), with the highest prevalence in 2019 (73.11/10,000) and the lowest prevalence in 2017 (54.23/10,000).

Results The serum levels of 25(OH)D, 25(OH)D3, and F25(OH)D showed a decreasing trend ( z = −2.781–−3.996, P < 0.01) in RA patients with CKD progression from mild to severe, while C3-epi-25(OH)D3 showed an increasing trend ( z = 6.741, P < 0.001) and 25(OH)D2 showed no significant difference among the groups ( z = 0.976, P = 0.329).

A decreasing trend in macular ChT ( P < 0.001) and SE ( P < 0.001) but an increasing trend in AL ( P < 0.001) and the presence of MAM ( P < 0.001) were observed in the eyes with PMs only, with both PCs and PMs and with PLHs, PCs, and PMs.

There was an increasing trend with the average annual increase rate of $1.23 ( P < 0.001).

An increasing trend in the quantity of average vaping was found over time ( BF (14, 130.955) = 0.954 p < 0.001), although the Bf < 3 ( Table 1 ).

This was followed by a positive trend change with an IRR of 1.004 (95%CI 1.001–1.008, P = 0.017) that resulted in an increasing trend over the post-reform period: IRR of 1.002 (95%CI 1.001–1.003, P < 0.001).

There was an increasing trend in the percentage of people prescribed opioids in the 25–49 mg/day group from 40.1% to 51.3% ( P <0.001), with the increase being more predominant for the opioid-naive and prior exposed groups.

The move towards more demanding cases had an increasing trend over the years ( P <0.001).

Overall, the annual scrub typhus incidence had an increasing trend over the seven-year period (Cochran-Armitage trend test, z = 101.85, p<0.001).

The proportion of adenocarcinoma showed an increasing trend with staining intensity (57.6% in IHC 1 +, 73.5% in IHC 2 +, 87.1% in IHC 3 +; chi-square = 26.7, P < 0.001).

However, when time was incorporated as a continuous variable in our analysis, there was an increasing trend in MMP-9 activities over time ( p = 0.001).

Chi-square tests for trend showed that the overweight and obesity rates of preschool children in Fujian Province presented an increasing trend with the increase in age ( p < 0.001).

An increasing trend in mean HbA1c was found in healthy and high-risk hosts (healthy hosts, 0.07 ± 0.02% [ P < 0.001]; high-risk hosts, 0.10 ± 0.03% [ P < 0.001]; Table 2 ).

There was an increasing trend in solid tumors (80.6% vs. 70.7%, p < 0.001).

Time trend analysis revealed that an increasing trend was observed for age at diagnosis ( p = 0.001), proportion of patients without a reproductive history ( p < 0.001), postmenopausal patients ( p = 0.001), invasive pathological cancer type ( p = 0.008), ER-positive rate ( p < 0.001), PR-positive rate ( p = 0.008), and HER2-positive rate ( p < 0.001).

All sentiments in “negative emotions” display an increasing trend, with anxiety (n=114,234, 18.59%, β 1 =0.12%, P <.001) and anger (n=106,767, 17.38%, β 1 =0.17%, P <.001) showing relatively strong upward trends compared with sadness (n=23,609, 3.84%, β 1 =0.05%, P <.001).

It showed that feces COX-2 mRNA is expressed in CRC, colorectal adenomas, and normal control group, which showed an increasing trend; the difference was statistically significant (χ 2 = 13.842, P = 0.001) [ Table 1 ].

The theft rate exhibited an increasing trend before the pandemic, with a monthly significant increase of 2.1% (IRR = 1.021; P < 0.001).

As shown in figure 2F , the normalised MEP amplitudes in YG group showed an increasing trend at 5 min (120.18% (109.88%, 131.45%), p=0.001), 10 min (123.51% (114.37%, 133.39%), p<0.001) and 30 min (116.97% (107.56%, 127.21%), p=0.004) compared with baseline.