“an unexplained trend”

However, we again observed an unexplained trend of freezing deficit in non-transgenic males treated with bexarotene as compared to vehicle- and bexarotene-treated APP swe / PS1 ΔE9 males (Figure 3 B).

Of note, an unexplained trend in increased platelet count was also reported earlier upon LOX inhibitor administration, 35 although the dosage of inhibitor used in that study was low, and was tested in newborn to young mice.

Even though we tested a model with an unexplained trend in transmission ( Table S2 ), more complex temporal functions may be required to fully capture such changes.

General results from SAGhE do not support a carcinogenic effect of rGH, but highlight an unexplained trend in cancer mortality risk in relation to GH dose in patients with previous cancer, and the indication of possible higher risk for bone and bladder cancers and Hodgkin’s lymphoma [ 6 ].

In some instances, (such as TFF1 ), combining chromatin modifying agents with fulvestrant resulted in stronger downregulation than either single agent, although this coincided with an unexplained trend towards increased ER occupancy at ER target gene promoters and enhancers compared to each single agent.

However, total bilirubin, albumin, aspartate aminotransferase, and alanine aminotransferase did not differ between the groups at the end of the study and there was an unexplained trend toward increased mortality in the bezafibrate combination group.