Barely Significant
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borderline significance

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borderline significancep = 0.0541.1× alpha
This GLMM-based sensitivity analysis aligns closely with the primary results, reinforcing a non-significant early trend and a stronger long-term protective effect against radiological progression, with the 60-month finding achieving statistical significance in the OR model ( p < 0.001) compared to borderline significance in the RR model ( p = 0.054).
borderline significanceP = .0541.1× alpha
Tertile-based analysis revealed a nonlinear dose–response pattern: compared with T1 (2.0–19.8 mmol/L), T3 (24.0–51.0 mmol/L) exhibited persistent protective effects in logistic regression (Model 3 OR: 0.77, 95% CI: 0.64–0.93, P = .006) and Cox (Model 3 HR: 0.78, 95% CI: 0.66–0.92, P = .003) models, while T2 (20.0–23.9 mmol/L) exhibited borderline significance in logistic regression (OR: 0.85, P = .054) but remained protective in time-to-event analysis (HR: 0.79, P = .002; Table 4 ). 4.
borderline significancep = 0.0541.1× alpha
The favorable prognostic impact on PFS of SOCS1 mutations described in the prior report [ 36 ] was maintained, although with borderline significance, also in the cohort analyzed by the present study (2-year PFS 93% vs. 70%, p = 0.054), while there was no evident impact on OS (100.0% vs. 86.8% at 2 years, p = 0.167).
borderline significancep=0.0541.1× alpha
Active travel showed borderline significance in increases in transport mode satisfaction compare to car (OR 1.86, p=0.054). 4 Discussion 4.1 Main findings The aim of our study was to examine transport satisfaction with usual mode of transport, explore the impact of journey destination, sex, age, car access, urban/rural classification, health and socio-economic status as moderators of the likelihood of transport satisfaction, and explore any changes in transport satisfaction in these variables over time.