“highly significant”

A highly significant L × W interaction was observed ( p < 0.001), indicating that the magnitude of the effect of wool content varies with fibre length (and vice versa).

The difference across main branches was highly significant (χ 2 (3) = 63.5, p < 0.001; Cohen’s w = 0.63, large effect).

Kaplan–Meier curves stratified by HF status continued to show highly significant differences at the threshold of 7000 for NT-proBNP, for all-cause death, cardiac death, and HF hospitalization (log-rank p < 0.001). 4.

The tests of between-subjects effects indicated that Factor A (face yarn type) had a highly significant influence on the thermal resistance of the garment ensemble (F(5,36) = 28.874, p < 0.001, η 2 p = 0.800), upper garment (F(5,36) = 23.768, p < 0.001, η 2 p = 0.768), and lower garment (F(5,36) = 20.668, p < 0.001, η 2 p = 0.742; see Supplementary Table S1 ).

The interaction is large and highly significant (F = 44.59, p < 0.001; Adj SS = 13.583 MPa 2 , ≈24.8%), confirming that the influence of T depends on the chosen layer height and vice versa.

All four independent variables had a highly significant effect on gene expression ( P < 0.001).

Nevertheless, most associations showed highly significant p -values ( p < 0.001) together with moderate to large effect sizes (Cramer’s V), supporting the robustness of the findings despite the absence of statistical adjustment.

The results revealed highly significant differences ( p < 0.001) among sensors for all three climatic variables, confirming the presence of pronounced spatial heterogeneity within the greenhouse.

Both its linear and quadratic effects were highly significant ( p < 0.001).

Notably, AlTPS1 and AlTPS40 demonstrated a highly significant positive correlation with Gansongone (P < 0.001).

Relative water content Analysis of variance showed highly significant effects of cultivar and treatment on RWC, with a strong year × cultivar × treatment interaction ( P < 0.001, Table 1 , Fig. 2 ), confirming RWC as the most drought-sensitive parameter.

The non-parametric Friedman test yielded a highly significant result ( p < 0.001), indicating that the ICC values varied notably between the Original Images, Histogram Equalization, Standard CLAHE, and Advanced CLAHE methods.

Remarkably, the validity of such a finding can also be questioned, despite a highly significant z-value (z = 33.346, p < 0.001).

Mycobiont identity emerged as the primary driver, with a highly significant effect ( F = 27.94, p < 0.001).

The post-intervention between-group difference was highly significant ( P <0.001), demonstrating superior efficacy of the combined psychological-respiratory intervention for enhancing functional capacity in COPD patients compared to conventional care.

In contrast, one-way ANOVA revealed highly significant differences in the mean mPI between the three groups ( P < 0.001, Table 5 ).

Notably, coronary artery involvement was confined to wave 1, where 31.2% of patients had mild dilatation with < 2.5 Z- score, while it was absent in waves 2–4, yielding a highly significant overall difference ( p = 0.001).

Similar dynamics were observed for the aminoglycosides AMI and TOB and for the polymyxin COL, all exhibiting highly significant time-dependent MIC shifts ( p < 0.001).

The Mann-Whitney test indicated this difference was highly significant (P < 0.001).

* P < 0.05 was considered significant, ** P < 0.01 was considered highly significant, and *** P < 0.001 was considered very highly significant.

Inferential statistical analysis using the Kendall’s tau-b test confirmed a highly significant upward trend (τ = 0.99, p < 0.001) in the number of practicing neurosurgeons per 100,000 inhabitants between 2000 and 2021.

The results demonstrated a highly significant relationship between higher knowledge levels and being aged between 38 and 47 years ( χ 2 = 446.211, p < 0.001).

The difference between the two slopes was highly significant (β2 = − 0.053 m/s per % BAI, p < 0.001).

The statistical significance of this clustering pattern was further confirmed by permutational multivariate analysis of variance (PERMANOVA), which demonstrated that the epididymal region was a highly significant factor shaping the metabolic profiles ( R 2 = 0.50, p = 0.001).

Liver enzymes: AST decreased from ~ 70 U/L at baseline to ~ 20 U/L at 6 months, and ALT declined from ~ 100 U/L to ~ 25 U/L, both showing highly significant improvements ( P < 0.001).