“highly significant”

The summary data showed that the association with the concurrent presence of the three antibodies was highly significant (Fig. 1C , 3 Ab vs . 0 Ab: OR = 2.00, p = 4.4 ×10 −16 , I 2 = 17%), and significantly stronger than the observed with the patients carrying two antibodies when directly compared (3 Ab vs . 2 Ab: OR = 1.54, 95% CI 1.29–1.84, p = 1.4 ×10 −6 , I 2 = 12%).

We observed a highly significant correlation of R = 0.66 ( P ‐value = 5 × 10 −16 ) for the 115 markers represented by the grey (non‐replicating) and orange (replicating) dots.

This functional pathway analysis is highly significant with p < 5 × 10 −16 . 3.

The association of HERC2 and SLC24A5 with eye color is also apparent in individuals who do not have blue or green eyes: In the subset of 592 Cape Verdeans whose T-index >0.15 ( Figure 1 , Figure 2 ), both loci remain highly significant ( HERC2 rs12913832, P = 5.23×10 −16 ; and SLC24A5 rs2470102, P = 1.12×10 −10 ), indicating that variation at these loci affects different shades of brown eye color.

This association of mimps with SIX gene promoters is highly significant (chi-square test p = 5.25E-16 for association by chance of mimps with the six known SIX genes on the Fol4287 pathogenicity chromosome).

Against a background of 19,297 protein-coding genes, this corresponds to a highly significant enrichment (hypergeometric test p-value = 5.9×10 −16 ).

This revealed marked and highly significant reductions in total dendrite length in both apical (p=6.02×10 −16 ) and basal (p=4.75×10 −14 ) compartments of Cd40 -/- mice compared with Cd40 +/+ littermates ( Figure 1C ).

In addition, there was the fourth cluster: (4) "Response to chemical and xenobiotic stimulus, drug metabolism", including the highly significant pathway "Drug metabolism–cytochrome p-450" ( p < 6.25e−16) containing cytochrome P450 enzymes (CYP2C, CYP3A, CYP26, UGT, GSTs).

A multivariate regression analysis of age-adjusted PAI-1 (dependent variable) reveals highly significant associations with liver density (P=6.3x10 -16 in Model I) and VAT volume (P=1.0x10 -13 , Model II in Supplementary Table 3.3 ) even after adjusting for BMI and other confounders.

We also found highly significant negative correlations of tumor purity with both immune scores (Pearson r = −0.988, P-value = 6.42 × 10 −16 ) and stromal scores (Pearson r = −0.917, P-value = 1.36 × 10 −8 ).

The log-normal regression (script 1, Supplementary material 1 ) revealed: (i) a highly significant influence of the zones ( p = 6.600e−16) and the season ( p = 6.219e−08) ( Fig. 4 ).

Combined analysis of the GERAD1 and EADI1 data yield highly significant support for all three loci ( CLU meta- P =6.7×10 −16 , PICALM meta- P =6.3×10 −9 , CR1 meta- P =3.2×10 −12 ).

2 C), and the difference from SBS homomers is highly significant ( Fig. 2 G, p = 6.9e − 16, ANCOVA for distances 25%–60%).

While the baseline tracking time for short words did not differ significantly between L1 and L2 readers ( p >0.05), the group × length interaction was highly significant ( p < 7 e −16), indicating that L2 readers show a steeper increase in tracking time for long words compared to L1 readers.

This module also demonstrated a highly significant hypergeometric enrichment ( p = 8e-16; Supplementary Table S3 ) with the mouse “yellow” module, which we previously showed was enriched with microglia genes as well ( p = 2.28e-37).

In expectation with known gene families involved in insecticide resistance, we observe highly significant enrichment for many GO terms relating to detoxification, such as oxidoreductase activity (fdr-corrected p value = 8e-16), iron ion binding ( p = 4.75e-15), heme-binding ( p = 6.8e-14), monoxygenase activity ( p = 9e-14), glutathione activity ( p = 0.001) and glutathione metabolic process ( p = 0.001), and the ‘P450’ ( p = 1.6e-16), ‘GST_N_3’ ( p = 0.002) and ‘GST_C’ ( p = 0.004) protein domains.

A highly significant positive correlation ( r = 0.74, P value = 8.8*10 −16 at 95%, CI = [0.62,0.82]) of BC with infection counts and with Death considering 10 days lag ( r = 0.84, P value = 2.02*10 −13 at 95%, CI = [0.73,0.91]) for the entire period, supports the above interpretation ( Fig. 2 (a, b)).

With additional adjustment for visceral fat, the association between rs738409 and percent liver fat was highly significant ( P = 8.88 × 10 −16 ; data not shown).

To determine the biological relevance of TDP-43-regulated APA, we studied its effects on microtubule affinity regulating kinase 3 (MARK3), a highly significant ( P = 9.4 × 10 –16 ) hit from APA analysis of ALS/FTD frontal cortex neuron nuclei containing or depleted of TDP-43.

Combining replication evidence from all 6 cohorts revealed an overall highly significant deviation from the expectation under the null (KS test p = 9.7 × 10 −16 , Fig. 4h ).

4 ), and this difference is highly significant (Wilcoxon rank-sum test, P < 10 − 15 ).

Not surprisingly, all pairs of correlations are highly significant with p -values < 10e-16 (alternative hypothesis: true correlation is not equal to 0).

Shapiro-Wilks tests of Normality were highly significant ( p < 10 −15 ) for both groups, and so measures of means and variances were not appropriate characterizations of the distributions.

The difference between imprinted and other monoallelically expressed genes was highly significant ( p < 10 –15 ), which is consistent with the imprinting mechanism, when an allele is expressed or silenced due to its parental origin without regard to the presence of a specific base.

Results A highly significant variation among all individuals and within each breed was observed in the number of duplications ( P < 10 −15 ) and in the number of deletions ( P < 10 −15 ).