These gradients were highly significant ( P < 0.0001), independent of malignancy and robust to neighbourhoods of diverse radii (Extended Data Fig. 3g,h ).
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Our IPO reconstruction exhibits highly significant agreement with instrumental IPO data from 1880 onward ( r = 0.85, P ≤ 0.0001; 1880 to 1995).
The multivariate analysis performed on all healthy dogs shown no age influence ( P = .2363), but a highly significant breed effect ( P < .0001).
However, lambda FLC expression showed a highly significant correlation with decreased BCSS (chi-square=18.0, p <0.0001), DFI (chi-square=15.2, p <0.0001), DM (chi-square=13.6, p =0.0002), and tumor recurrence (chi-square=17.6, p <0.0001) (Figure 2C ).
The decrease in the incidence of CDI in the second period compared to the first period was highly significant (0.11% vs. 1.21% respectively; p = 0.0001) ( Figure 1 ).
Both models were highly significant ( p < 0.0001), with adjusted coefficients of determination (R 2 adj ) between 0.72 and 0.78.
This results in a highly significant difference ( p < 0.0001) in BMI as well as our new index when compared between the non-infected and infected cohorts.
In the early-harvest panel, the difference in defoliation by subspecies was highly significant ( P <0.0001; Table 1 ).
At 0–6 m, hippocampal loss in mild cognitive impairment and Alzheimer's disease was already highly significant ( P < 0.0001), whereas the loss in normal became significant in the 0–12 m interval only ( P = 0.005).
These effects were highly significant after adjustment for multiple comparisons (p<0.0001, Table S2 ).
Our measurements showed that MCF-10A had a small, yet highly significant, preference to grow on 2D conditions compared to control 3D ECMs (1.1 fold, with P < 0.0001) or tumor-associated 3D ECMs (1.3 fold, P < 0.0001).
Advanced disease stage of the disease led to a highly significant P = 0.0001 for fatigue.
The left (not surgically destabilized) and the right (surgically destabilized) knee joints of the rats were highly significant different ( p < 0.0001) when comparing all animals of both groups (treated with dPGS or not).
The log ‐ rank test showed a highly significant result ( p < 0.0001), as depicted in Figures 2 and S1 .
A highly significant reduction ( p < 0.0001) was also found in the invasion of the co-culture by the HMLN-1 strain when it was co-inoculated (65.6%) and pre-inoculated (97%) with L. reuteri M4-100 ( Figure 3 ).
All correlations were highly significant (p<0.0001).
The lactation number was highly significant ( p < 0.0001) when comparing LCS groups, as well as the age of the animals ( p < 0.0001).
When PLM and PLM R scale distributions were compared, the difference in both cohorts was highly significant (ANOVA, p < 0.0001).
Importantly, translationally activated mRNAs present higher mean PARS values in the CDS (0.49) than all genes (0.37) and higher than those mRNAs translationally repressed (0.33) or not affected (0.27), with these differences being highly significant ( P ≤ 0.0001) ( Fig. 5 B).
In all areas that were analyzed (CA1, CA3, hilus, and dentate gyrus), there was a highly significant main effect for group ( p < 0.0001 for all areas) but not for treatment (CA3: p = 0.2708; CA1: p = 0.6038; dentate gyrus: p = 0.6610; hilus: p = 0.8269).
Results In 53 studies of dystonia phenotypes, the proportion of men showed a highly significant negative association with mean age of onset ( p < 0.0001, pseudo- R 2 = 59.6%), with increasing female predominance from 40 years of age.
In addition, we discarded SNPs with a minor allele frequency (MAF) <0.1% over the entire data set or with a highly significant departure of individual genotype frequencies from Hardy-Weinberg equilibrium expectations ( P < 10 − 4 ) in at least one population.
By aggregating the two subgroups with low risk and three subgroups with medium risk, patients could be assigned to three risk groups (high, medium, low) with a highly significant ( p < 0.0001) five-fold difference in risk (Table 5 and insert in Fig. 2 ).
According to the model fit statistics, the quadratic model is suggested to be highly significant among linear, 2-factor interactions (2FI), and quadratic models for turbidity ( p = 0.0001), COD ( p = 0.0004) removal, and residual Al ( p = 0.0274) implying high correlation coefficient (R 2 ) values, 0.9831, 0.9838, and 0.9775, respectively.
longicolle at this site was statistically highly significant ( χ 2 = 64.3, P < 0.0001).