“highly significant”

The difference in the mean time of rescue analgesia was statistically highly significant when Group A (gabapentin) was compared with Group C (placebo) (P value<0.001) and when Group B (pregabalin) was compared with Group C (placebo) (P value<0.001).

Among all modules, the BLUE module showed a highly significant positive correlation with senescence scores (r=0.75, P<0.001) ( Figure 2C ).

The intervention level change ( β 2 ) was negative and highly significant for all four drugs (Newey-West p < 0.001), reflecting an immediate and drastic reduction in procurement cost per DDD.

Moreover, the results remained highly significant when accounting for guarantee-time bias ( P < 0.001; HR = 0.03; 95% CI, 0.01–0.06; Supplementary Table S3).

Co-expression analysis of the genes The Spearman correlation analysis between NBN and OGG1 gene expression reveals a moderate positive correlation with a Spearman’s rho of 0.46 and a highly significant p-value < 0.001 (Fig. 5 e).

Administration of AlCl 3 to rats caused a highly significant ( p < 0.001) decrease in glutathione reductase activity by 44% when compared to that in the brain of control rats.

The combination of adequate statistical power and highly significant p-values ( p < 0.001 for maximum comparisons) provides strong evidence in support of our performance claims.

This is supported by a highly significant correlation ( r = 0.405, p < 0.001) between Melatonin and NREM sleep (Figure 2 ). 3.8 ICP Mean ICP values remained near zero or slightly negative in the afternoon and morning but peaked around the time of maximal NREM sleep (Figures S2 and S4 ). 3.9 Electrolytes The normalised levels of all electrolytes showed minimal variation, which remained within ±1% throughout the study period (Figure S3 ). 3.10 Cosinor Analysis Finally, we conducted a cosinor analysis to investigate the circadian rhythms of Aβ42, hypocretin and ICP.

The results of the two-way ANOVA ( Table 2 ) indicated that growth period had a highly significant main effect on the Shannon, Simpson, Chao1 indices ( p < 0.001).

Individual linear regression plots demonstrated highly significant linear relationships between eGFR and protein levels for HLA-E, EFNA1, EPHA2, FSTL3, ART3, GM2A, CLEC1A, CKAP4, GPR158, and IFNGR1 (all P < 0.001), with Pearson correlation coefficients typically ranging from -0.4 to -0.6.

After 30 h of culture ( Figure S1 ), the growth assayed by optical density analysis, which showed a highly significant difference between the Kruskal–Wallis test of H (4) = 45.203 ( p = 0.001) and the Bonferroni correction.

After the first year of therapy, discontinuation due to an adverse event was low (∼3% per year) and among the patients who did not stop therapy or stopped it for a short time (≤30 days), the benefit of ticagrelor in terms of reduction of ischaemic events was highly significant (ticagrelor 60 mg bid vs placebo: HR 0.79, 95% CI 0.68-0.91; p < 0.001) 147 .

We found a highly significant correlation between LRP6 protein and mRNA levels in TNBC (Figure 1J , correlation coefficient=0.75, P <0.001).

A highly significant loss of luminal marker expression ( p < 0.001) was observed in the course of progression whereas an increase of basal marker expression ( p < 0.01) was noted in the invasive compartment.

In all the statistical evaluations, P < 0.05 was considered significant, P < 0.01 was considered highly significant, and P < 0.001 was considered very highly significant.

For both ERs and RTs, the GEE showed highly significant main effects of Age Bin (χ 2 = 674, p < .001; χ 2 = 1081, p < .001) and Trial Type (χ 2 = 551, p < .001; χ 2 = 37, p < .001), and Age Bin*Trial Type interaction (χ 2 = 28; p < .001; χ 2 = 63; p < .001).

Notably, although mechanical ventilation and vasopressor use were highly significant in univariate analysis ( P < 0.001), they were not retained in the final model after stepwise regression, likely due to their collinearity with severity scores.

There was a highly significant (p < 0.001) combined effect of R25C and UASMS2 on the variability of back-fat thickness.

Comparisons of the OR between the experimental and reference categories were considered significant at p < 0.05 and highly significant at p ≤ 0.001.

The model revealed a strong positive relationship between chromosome size and kinetochore size, with an estimated slope of 0.392 that was highly significant ( P < 0.001; Fig. 2 and Table 1 ).

Threshold shift showed a highly significant difference for all frequencies and for both time points compared to the pre-exposure levels ( p < 0.001).

Similarly, the mean Russell’s index scores were 0.18 ± 0.07, 3.72 ± 0.39, and 2.96 ± 0.66, respectively, with a highly significant intergroup variation (F(2, 87) = 556.28, p < 0.001).

The median PFS was markedly shorter in the PPI group, and the difference was highly significant (log-rank P<0.001).

Leaf relative water content, water potential and surface temperature The results of the ART-ANOVA analysis revealed that, during the drought phase, both drought ( D ) and temperature ( T ) had highly significant effects ( P < 0.001) on RWC, LWP and LST ( Supplementary Table S1 available as Supplementary Data at Tree Physiology Online).

When the two biofluids were compared directly, serum E-cadherin levels were consistently higher than salivary levels in both groups, and this difference was highly significant ( p < 0.001).