“may be significant”

82 Despite knowledge of the importance of the avoidance of weight gain in people with SMI, there is a paucity of evidence for the acceptability of metformin among people with SMI and, in particular, among younger people for whom factors such as pill burden may be significant.

Since the AKR inhibitor 5β-cholanic acid is a well-tolerated naturally occurring bile acid in humans, and since flufenamic acid has been used in clinical trials with manageable toxicities [ 41 ], there may be significant value in conducting clinical trials in which either 5β-cholanic acid or flufenamic acid are co-administered with doxorubicin during chemotherapy.

Studies in Sprague-Dawley rats suggest that orexinergic neurons may be significant targets for ketamine, with orexin A (OXA) neurons reducing the duration of ketamine-induced anesthesia [ 110 ].

This suggests there may be significant crosstalk between zinc and iron signaling, and further research could uncover additional mechanisms linking the signaling of various metals.

These results implicated that ING proteins may be significant modulators of p53 function.

Additional analysis of oscillatory solute dispersion within PVS indicates that advection rather than dispersion is likely the primary transport mechanism for dissolved compounds greater than 66 kDa in the long (> 2 mm) perivascular segments identified here, although dispersion may be significant for smaller compounds in shorter perivascular segments.

Nest site may be significant in the first model predicting relatedness (which is, because λ = 0, equivalent to an ordinary least squares model) because this trait is phylogenetically correlated with colony size and highly conserved in the genera Vespula and Dolichovespula .

Note that mediation tests may be significant for many reasons other than reflecting genuine mediators ( 50 ).

However, in the case of systems with 3D architecture based on AAO, which provide a high aspect ratio of pore length to pore diameter, this effect may be significant.

Such shifts may be significant, as they could influence how the protein engages with potential inhibitors.

These findings suggest that it is possible to treat the downstream effects of mitochondrial dysfunction with Boswellia Serrata in FM, which may be significant in identifying the underlying pathology of FM.

The study's finding of a correlation between Vt in CE and VE FMV techniques and the size of the operator's hand may be significant in the field of teaching airway management.

These costs may be significant and should not be ignored.

In the case of acute exposure, abdominal radiographs may demonstrate radiodense lead foreign bodies in the gastrointestinal tract, while long-bone radiographs may be significant for visible lead lines (lines of increased density on metaphysis), signifying growth retardation from chronic exposure [ 7 ].

The genes involved in both biological processes may be significant.

We observed a positive correlation between various individual risk factors (e.g., noise, ototoxic medications, smoking), which, though minor on their own, may be significant for PEUs due to their above-average hearing abilities.

In mild cases, there may be significant clinical discomfort; while some patients may experience pulmonary embolism and nerve damage, and even paraplegia or death in severe cases. 5 Therefore, to systematically identify the independent risk factors for bone cement leakage during PVP and establish a clinically applicable predictive model, this study retrospectively analyzed perioperative data from OVCF patients.

These alterations may be significant in clinical practice for the accuracy of IOP measurements and the eligibility of individuals with diabetes for keratorefractive surgeries.

Morbidity such as limb loss may be significant, and mortality rates of 7% are quoted in the literature. 1,2 As well as damage to the vasculature, intrapelvic displacement of arthroplasty components beyond the pelvic inlet may damage the sciatic and obturator nerves, the ureters, bladder, bowel and pelvic organs.

A further difference from natural host populations that may be significant to parasite virulence is the often low level of genetic variation in farmed host populations, which may favour the spread of diseases (Altermatt and Ebert 2008 ; Ganz and Ebert 2010 ).

Secondly, our analysis does not include copy number variation analysis or methylation analysis, as some of this variation may be significant in cancer predisposition risk, therefore, prevalence calculations might be slightly underestimated.

These data suggest that there may be significant associations between sustainable behaviors pertaining to medication use and the knowledge level regarding environmental risks of PECs and their source control from a One Health perspective among Chinese pharmacy students. 3.4 Attitudes toward environmental risks of PECs and their source control from the perspective of One Health Table 4 demonstrated that, in general, pharmacy students held positive perceptions toward environmental risks of PECs and their source control from the One Health perspective.

The present study has further demonstrated the use of combined CYFRA 21-1 and CRP as a prognostic marker in OSCC and may be significant as a biomarker to predict prognosis and stratify patients for adjuvant therapies in the absence of traditional indications such as lymph node ECS.

This indicates that the effects of noise during sleep may be significant in developing breast cancer, potentially disturbing the circadian rhythm [ 136 ], which is a suspected risk factor for breast cancer [ 142 ].

Finally, due to the limitations of convenience sampling, there may be significant differences in gender distribution within our study.