Barely Significant
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may be significant

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In the literature

Additionally, the activation of CB2 receptors and the modulation of iNOS/eNOS cardiac equilibrium may be significant mechanisms for mediating the cardioprotective impact of the synthetic cannabinoid agonist, WIN55,212-2, towards ischemia–reperfusion injury in an experimental model of type 2 diabetes [ 46 ].
Our findings reveal that up to 6 % of women of childbearing age remain HCMV seronegative in Pakistan, and the risk of primary infection within this group may be significant given our observation that around 0.5 % of men of a similar age may be undergoing primary infection each year, an event followed by prolonged viral secretion, which could serve to drive infection in the women who remain uninfected at this age.