“may be significant”

It may be significant that, as shown in the PONDR ® plot in Fig. 6 , the A3 epitope that is capable of inducing spreading and autoimmune disease like the EBNA1 epitope shown in Fig. 5 , is in a strongly ordered region located adjacent to regions of strong disorder of the PONDR ® plot.

NMR-style analysis of Vc INDY ( Sauer et al, 2022 ) indicates that there may be significant structural plasticity around the substrate-binding site before Na + binding, preventing it from the binding substrate; however, binding of the Na + ions could then stabilize the HP loop structures, facilitating stable substrate binding.

25 Thus, frailty assessment in elderly populations may be significant for patient management personalization, allowing reduction in both excessive complications and costs of undertreatment and overtreatment. 40 , 42 – 44 However, the lack of consensus for a universal definition of frailty for clinical use limits the application of the diagnosis of frailty syndrome in clinical practice.

This observation suggests that there may be significant bias due to P -element insertion hotspots.

Considering that largely young males were included in the survey portion of the study, there may be significant impact on the results given that this group rarely has needs for screening in general, and I'm unaware of any immediate needs for cancer screening outside of Circle cancer, screening and women.

Both alterations may be significant for ligand-independent ER activation with loss of the inhibitory effect of tamoxifen on ER-mediated transcription, providing a viable mechanism to explain the association of Her-2/neu with tamoxifen resistance 22 .

This suggests that variation in FSIQ scores may be significant regardless of genetic subtype.

It may be significant that the fraction of FasL + thymocytes in the H-Y TCR Tg line is substantially lower than that in the other Tg strains (see Discussion).

The family history may be significant in X-linked–dominant patterns for disproportionate short stature, leg deformities, dental abscesses, periodontal disease, and hearing loss along with osteoarthritis, enthesopathy, and (pseudo) fractures [ 2 ].

Our results suggest there may be significant sex-associated specificity limitations with the EI assay.

Finally, other factors that may be significant determinants of BC screening utilization have not been recorded in the current study [ 20 , 21 , 42 , 45 ], such as promotion of BC screening by the government, cancer leagues, medical organizations and lay press.

Third, these findings suggest that there may be significant unmet need for endodontics within the population and this should be addressed in line with national recommendations for primary dental care redesign [ 24 ].

These findings validate DJ-1 as a promising therapeutic target in Parkinson's disease and identify a novel peptide with clinical potential, which may be significant for a broader range of neurological diseases, possibly with an important impact for the neurosciences.

26 This unique structure of IgG 4 may be significant for the FVIII-mimetic activity of our bispecific antibody, and the result suggests that the Ser228Pro mutation may not change the tertiary structure of IgG 4 dramatically.

For example, the increased Humbug expression in CDS11 cells may be significant in relation to its Ca2+ binding effects in the ER [ 85 ].

Conclusions The study highlights that age, employment status, and a family history of anxiety disorders may be significant predictors of GAD in peripartum period.

Additionally, the activation of CB2 receptors and the modulation of iNOS/eNOS cardiac equilibrium may be significant mechanisms for mediating the cardioprotective impact of the synthetic cannabinoid agonist, WIN55,212-2, towards ischemia–reperfusion injury in an experimental model of type 2 diabetes [ 46 ].

However, since these antibodies describe a novel class of autoantibodies that are high affinity for DNA de- spite being germline gene encoded, and it has been shown that CDR3 is important for DNA binding, it is possible that the usage of the DFL16 family may be significant.

Modeling of the protein also suggests that there may be significant size and/or shape constraints on the structure of the hydroxamic acids.

Cell damage from oxygen free radicals (OFR) is ubiquitous and may be significant in the expansion of tumor clones and the acquisition of malignant properties [ 135 ].

[ 28 ] found that when using the multi-point DID model for empirical analysis, there may be significant estimation bias due to the presence of a "heterogeneous processing effect." To this end, this paper uses the twowayfeweights command in STATA software to test the possible "heterogeneity" of the model, drawing on the practice of De Chaisemartin et al.

In order to better discern if the reported increases may be significant and attributable to anthropogenic activity or fall within the realm of the Region’s long-term drought cycle, a survey of climate literature relevant to Southeast Texas was conducted to provide contextual relevance for the statistical analysis performed in this study.

The homogeneity of the sample (healthy volunteers) limits the generalizability of the results to populations with comorbid conditions, where the discrepancy between biological and chronological age may be significant.

The efficacy and safety of immunotherapy with DPCP in pediatric alopecia areata has been well documented.[ 5 ] CONCLUSION We report the association of alopecia areata with a rare genetic syndrome-BPES, which may be significant considering the surfacing evidence on the genetic basis of alopecia areata.

This may be significant as discontinuations due to AEs seem to occur soon after commencing treatment [ 20 ].