Barely Significant
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may be significant

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In the literature

( 14 ) confirmed the role of IGF-1 as an important autocrine or paracrine regulator of smooth muscle cell proliferation, and suggested that it may be significant in determining the cellular response in rat aortas after balloon denudation.
The Endothelium in Acromegaly.
Front Endocrinol (Lausanne) · 2019 · PMC6667653
EGFR amplification/mutation and mTOR mutations may be significant resistance mechanisms associated with BRAF-targeted therapy, as signalling through the EGFR/PI3K/AKT/mTOR cascade overcomes the block on BRAF/MEK to continue cell proliferation. 116 This phenomenon should be explored further to identify the specific subsets of BRAF -mutant glioblastoma patients that may benefit from BRAF/MEK therapy alone and to clarify whether the addition of EGFR or mTOR inhibitors is required for BRAF-resistant tumours.