“may be significant”

This window of activity may be significant as tick-borne virus transmission occurs within 24 h of tick attachment, and possibly within the first hour of feeding [ 78 – 80 ].

The hypoxia-associated factor (HAF) might also promote ubiquitination and proteasomal degradation of neurofibromin, which may be significant during physiological hypoxia including embryonic development and wound healing, but may also play a driving role in the development and progression of hypoxia-associated cancers 148 .

Conclusion Our study identified genetic and social factors determining the degree of vulnerability to the negative effect of chronic stress on survival and additionally shows how agonistic behavior and social rank may be significant modifiers of healthspan, DNA methylation pattern, and lifespan.

According to network analysis, TNF, GAPDH, IL-6, AKT-1, IL-1B, and VEGFA are prospective therapeutic targets, while osthole, cauloside A, ammidin, angelicone, beta-sitosterol, and asperosaponin VI may be significant active components. 1705 biological processes (BP), 155 molecular functions (MF), and 89 cellular components (CC) were identified by GO analysis.

Local changes in small areas in metal levels in the feathers of raptors may be significant and not adequate 33 , while aquatic birds will rather reflect water pollution 27 , 34 , 35 , there are few studies on sedentary species leading a forest and field lifestyle.

We plan to study this problem in the future, referring to some application contexts where discriminating among different stages, associated to different populations, may be significant.

5 Despite their evolution and improvement (integration of advancing parameters such as age, sex, and immunity), 6 , 7 animal models still suffer from interspecies differences, which may be significant in translating data into human physiology. 8 Therefore, a gap remains in clinical trials of drugs for TBI.

While these so-called “soft” impacts on society are often indirect and intangible, their effect may be significant. 4 , 255 Therefore, we agree with others 88 , 192 , 256 that more efforts should be made to anticipate and evaluate the soft mid- and long-term impacts of TE and RM on society at large.

These slight behavioral changes may not have a statistically significant meaning but may be significant in changing the approach with the patients.

Thus, inhibiting local immune reactions during active inflammation may be significant in managing inflammatory ocular diseases [ 49 ].

Given the high prevalence of child stunting (ie, impaired growth) and other nutritional disorders in low-income and middle-income countries, where maize is consumed, the role of aflatoxin exposure may be significant.

There may be significant gender differences in the incidence of F-PNETs over time.

In particular, these last authors highlight that the influence of sample configuration is not significant in measuring Young’s modulus in CD, while it may be significant in MD due to stress concentration.

Limitations The limitations of this study include: (1) As a population-based analysis, we need to be very vigilant against ecological fallacies, and when explaining the results, we can only put forward the scientific hypothesis of the causality of the epidemic trend based on the existing data and previous literature rather than subjectively infer it; (2) There may be great discrepancies in the incidence among different pathological types of TC, which is not reflected in the GBD database; (3) There may be significant differences in incidence rate among different regions of the same country, especially in countries with a large population and a vast territory.

The literature indicates that there may be significant individual differences in the mechanism of PBC effect ( 44 ).

The decrease in vascular resistance and increase in blood flow of the arm may be significant indicators for a successful SGB.

Large differences in the distribution of optimal matched regions are observed in the short introns, but some distributions are very peculiar in that they may be significant and deserve to be studied in depth.

The potential interacting residues (Val-104, Phe-105, Gln-247, Arg-250, Ala-266, Trp-330, Tyr-331, Pro-334, Ala-335, Val-336, Tyr-357, Met-358, Thr-360, Glu-361, Ile-362, Arg-365, Asn-366, Asp-369, Arg-372, Trp-447, Tyr-475) identified by molecular docking analyses may be significant for site-directed mutagenesis.

A French series reported recurrence rates of 67%, indicating that the relapse rate may be significant [ 7 ].

10 , 11 Dietary approaches (whether alone or as augmentation) may be especially appealing to people with mood disorders who have mild to moderate symptoms and physical comorbidities, and therefore the potential impact on the wider population and economic factors may be significant.

The latter in particular may be significant, as reactive oxygen species could be stabilised via interaction with such structures and hence be more prolific and more effective at oxidising the cell membranes.

The presence of a sulphate moiety and/or a large molecular weight (430 kDa) in SCM-chitin may be significant factors in its antiviral action, as CM-chitin, which has no structural sulfate with a molecular weight of 63 kDa, has shown no inhibitory impact against FMuLV and herpes simplex virus [ 108 ].

It is worth noting the presence of other non- Saccharomyces yeasts in the lees, which may be significant from an oenological point of view, namely the genera Starmerella and Metschnikowia ( Figure 2 ).

Altogether, however, the results they published so far, further highlight the need to develop suitable cell models for drug testing, by clearly demonstrating that there may be significant differences between the results obtained in vitro in fibroblasts vs. neurons using the exact same therapeutic molecule.

Therefore, high short-term fluctuations in glucose levels, especially postprandial ones, may be significant in the occurrence of cardiovascular events by inducing endothelial dysfunction, inflammatory reactions, and oxidative stress which may lead to atherosclerosis [ 7 ].