“might be significant”

Response 2: entrapment efficacy (Quadratic model) entrapment efficiency analysis due to the effect of Variables The model's F-value of 12.25 suggests that it might be significant.

However, there might be significant differences between countries in Europe; for example, in Italy, France, and Spain, selling tobacco is allowed only for tobacco-specific retailers, and opposition from the retail sector will not be negligible when adopting such a policy 14 , 15 .

However, seed handling times, husking success rates and seed-handling skills have been observed to vary significantly even among adult individuals ( Andries et al., 2023a , b ), so individual variation in seed preferences might be significant regardless of age.

In addition, the potential multivalent nature of CBM92 glycan binding might be significant, as it could lead to the formation of protein-polysaccharide networks that may stabilise enzymes in a manner conceptually similar to the use of immobilisation in industry.

Methane production from hexadecane ( Table 2 ), a long-chain alkane, in some methanogenic slurries (e.g., Mercator MV) demonstrated that methanogenesis from saturated hydrocarbons might be significant in MV sediments as previously shown in other anoxic environments ( Zengler et al., 1999 ; Fowler et al., 2016 ).

In addition, an ongoing, long-term extension trial ( NCT01500551 , https://classic.clinicaltrials.gov/ct2/show/NCT01500551?term=01500551&draw=2&rank=1 ) might be significant in observing the long-term safety of tofacitinib in paediatric patients.

Even though not all genes were present in all samples, it was not possible to conclude whether differences between samples might be significant due to unavoidable variability in overall community complexity, assembly efficiency, MAG completeness, and uneven representation of less abundant taxa.

Even though this shift is quite small (0.2 Å on average), its effect on the CT properties might be significant, given the sensitivity of CT couplings to the distance. 20 The mutual orientation between the chlorophylls is conserved among the WT replicas and with the mutant, leading to a well-defined and consistent orientation of the Chl pair.

Even though SMD was used to understand DMDD in the present review, the relatively small difference between DMDD and SMD criteria might be significant and becomes evident when examining youths on a group level.

Therefore, the interference of serum TgAB in Tg-FNAB measurement might be significant when serum TgAB are higher and differences in cutoffs for both measurements should be considered in those situations.

Moreover, there might be significant differences in gene expression between rat and human intervertebral disc cells, potentially impacting cellular functionality and responses to external stimuli [ 62 ].

This approach surpasses the deficiencies of previous architectures that required Bonferroni correction for false rejections and returns additional as well as weak associations that might be significant.

In that respect, it might be significant that the FERM domain of NHERF1 binds merlin, which in turn binds to the PDZ1 domain of SYNTENIN1 ( 56 ), possibly altering the effects of SYNTENIN1 on EV formation.

According to the earlier literature, we suggested that GM alterations might be significant over the fronto-limbic regions.

These issues might be significant if the tools should be used in living animals.

Considering the invasiveness of the procedure, pwMS’ high expectations of aHSCT ( 27 ), and its influence on self-efficacy, we suppose that an accompanying placebo effect of aHSCT might be significant.

Finally, while the findings resonate with existing literature, the unique context and characteristics of our study population need to be considered when comparing these results with other studies, as there might be significant differences in patient demographics, healthcare access, and management strategies.

Although there seem to be similar retinal penumbra models and there might be significant inter-individual differences in retinal tolerance to ischemia [ 28 , 29 ], the retinal ganglion cells that form the optic nerve appear to undergo apoptosis already after only 12–15 min [ 40 ].

For instance, while pressure might be the significant parameter for extrusion-based bioprinting, the effect of energy source might be significant for the droplet-based bioprinting approach.

Therefore, since HERV-W is upregulated in a particular exercised individuals, it might be significant to identify this difference.

An important limitation of this study is that we did not explore gender differences, which might be significant.

Although not what the reviewer specifically meant, this comment did spur us to consider whether the three diffusion metrics from the five regions might be significant beyond the general aging of the whole brain.

Its capacity to inhibit the proliferation of cells triggered by the epidermal growth factor has been investigated, and this might be significant in the treatment of cancer.

Therefore, we conjectured that MKK4/5 might be significant in improving the drought resistance ability of S. miltiorrhiza .

Teachers’ perceptions about the relevance of information presented in the curriculum give rise to concerns that, given their daily interactions with students, it is important to acknowledge that there might be significant instructions on coping with RSBs and SRH information that are overlooked.