Barely Significant
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of borderline significance

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In the literature

Results Identification and structure prediction of the SELO domain In order to predict structure for the SELO protein, the FFAS03 [25] method was used, yielding consistent, albeit of borderline significance, predictions of kinase-like superfamily in the SCOP database ( http://scop.mrc-lmb.cam.ac.uk/scop/ ) and various families of the kinase-like clan (CL0126) in the Pfam database (see Table 1 and Table S1 ).
18 A fourth prospective study based on Australian participants (38% premenopausal), suggested a positive association with fT4 of borderline significance (OR per unit increase = 1.07 (0.99–1.17)), but included a more limited number of cases (n = 100). 15 Although one prospective study (n = 61 cases) reported higher breast cancer risk among postmenopausal women with low fT4 concentrations, 19 a recent, large Mendelian Randomisation analysis combining
observed that clinical bulky (≥2 cm) mediastinal lymph nodes was of borderline significance in predicting an increased risk of BM in IIB–IIIB NSCLC after multimodality treatment.[ 10 ] Wang et al. reported that a greater number of mediastinal lymph nodes and nodal regions with metastases predicted a higher risk of BM for stage III-N2 NSCLC.[ 13 ] Mamon et al. reported that the incidence of BM increased independently by the presence of residual nodal disease in 177 surgically treated IIIA (N2) NSCLC with/without neoadjuvant/adjuvant therapy.[ 11 ] In our study, on multivariate analysis, LNR ≥ 30 % was associated with an increased risk of BM and BM as the first relapse.