Provisionally significant genes (adjusted P < 0.0001) were analyzed for enrichment of KEGG pathway membership; enrichment was assessed for genes that showed increased or decreased methylation values separately.
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“provisionally significant”
Sighted at
p=0.073
In the literature
Individual genes were considered provisionally significant for p < 0.001.
For our mixtures analysis, individual genes were considered provisionally significant at p < 0.005 ( Lapehn et al., 2025 ).
Provisionally significant results of the same direction (i.e., p < 0.05, where NCGS respondents more often reported the condition), but which did not survive this correction, were also reported for thyroid disease and fibromyalgia.
Likewise, we observed a positive, provisionally significant, association between fibrosis grade and early recurrence in our cohort.
The resulting p -value less than 0.01, 0.05, and 0.1 will be considered statistically highly significant, statistically significant, and statistically provisionally significant, respectively.
Furthermore, using a slightly relaxed p -value cut-off ( p < 0.1), 4 of the 7 hub-genes (DCAF11, PKM2, DGAT2 and BCAT1) showed provisionally significant differences between the survival kinetics of HCC patients exhibiting low and high expression levels of these genes, in terms of all three genera of survival.