“quite significant”

8 The available data regarding other Sub-Saharan African countries are sparse, although the few available studies show a quite significant prevalence of G1/G2 variants across Sub-Saharan Africa. 9 , 29 Based on cohort and cross-sectional studies in the United States, the estimated allelic frequency among African Americans is 20%–22% for G1 and 13%–15% for G2, with approximately 10%–15% having an APOL1 high-risk genotype. 9 The global prevalences of the G1 and G2 alleles and the high-risk genotype are difficult to discern, because these vary widely between regions, many populations are either not tested or have small sampling, and it can be difficult to identify ancestry or ethnicity given gene flow and admixture.

Such increase was minor in HL-60 cells (1.2-fold), as most MRTF-A was nuclear prior to the jasplakinolide treatment, but quite significant in knockout cells (2.3 and 2.5-fold).

Please also see previous comment, but the relevance of this and why this should differ between intervention and control is not clear - As mentioned in the results, the cost of 100K USD per clinic to implement ATP is quite significant and should be discussed.

This step is quite significant because long-term centralization and stabilization of a capsular bag fixated intraocular lens (IOL) are associated with the factors including anterior capsulotomy size and shape and integrity of the capsule edge.

In this context, and also bearing in mind that 98% of drugs cannot traverse the BBB [ 41 ], a 2 to threefold increase in brain penetration must be deemed quite significant and highlights the relevance of the present work.

7 , 8 Although the clearance is partial in many conditions, it is quite significant, therapeutically beneficial and can be increased via increasing the number of sucking cups and Al-hijamah sessions.

The correlations are much higher than on the first trial and are quite significant.

It can be noted that the difference between water and DRA is quite significant with increasing wind velocity and that at a lateral wind velocity of 10 m s −1 , the water coverage of the water-sensitive paper was already 24.3%, while it was 16.6%, 16.3%, and 15.6% for DRA1, DRA2, and DRA3, respectively.

This finding may be quite significant if these drugs are to be used for differentiation therapy of ALL patients in the clinic in the future.

However, given the extremely important differences in outcomes (no significant effect in ITT and quite significant effect in PP), I think that the authors should be clearer about which is the more relevant group/more significant finding and why.

N = 118) were also quite significant.

As they go up into higher rounds, the athletes face stronger competitors and accumulate quite significant metabolic fatigue substance.

Nine students wrote both compositions of week 4 and as can be seen in Table 5 , the mean difference in week 4 is again quite significant since it is 0.001.

dithane M-45. This observation is quite significant and opens up a new field of research where metal complexes of organic molecules are better fungi-toxic than commercial products, showing greater possibility of applicability of these complexes under field conditions.

Conclusion Evidence that reduced risk of certain somatic diseases is associated with schizophrenia is quite significant to progress in the evolutionary epidemiological analysis of psychopathology.

The increment in worldwide mean atmospheric carbon dioxide (CO 2 ) concentration from the pre-industrialization era of 1850 to date has been estimated at 285–419 ppm 5 , 6 which is quite significant.

It is important to note that the differences in drug release rates are quite significant; after 24 h only, <40% of the drug had been released from 10% of the pAAm hydrogels, whereas ca. 70% of the drug had been released from 2.5% pAAm hydrogels.

Although the silencing effect observed through RNAi in the current study is quite significant, from which about 60% of TCE2 gene’s expression was inhibited, it was still incomplete, which is similar to the RNAi effect observed from some other insects 47 .

A positive effect of salts on Young’s modulus is still quite significant for admixture-free concrete.

4f , it could be found that the intratumoural accumulation of PdH 0.2 nanocrystals at 2 h post injection is quite significant besides that associate with liver and spleen in support of passive tumour targeting by EPR effect.

Temperature has quite significant effect on the formation of MGO that the temperature increase from 100 to 120 °C more than doubled the MGO level.

Although the increase in length of the stroke is just a few centimeters, the gain can be quite significant over the course of the race.

This practice involves a certain, quite significant risk that patients with thrombocytopenia or an elevated international normalized ratio could be treated with recombinant tissue plasminogen activator.

Addition of 1C in the list of drugs effective against this bacterium is quite significant.

These effects are quite significant, for example, showing variations in the AL index up to 40% for opposite values of B y .