Topical Diacerein Decreases Skin and Splenic CD11c<sup>+</sup> Dendritic Cells in Psoriasis.

Int J Mol Sci · 2023 · PMC10001455 · PMID 36901755

Europe PMC DOI

hedged sentences

0.0665

closest p · 1.3× alpha

0.0762

boldest claim

The sentences

a strong trendp = 0.0665so close (0.05 < p ≤ 0.1)

Consistently, 10% diacerein showed a strong trend to reduce IMQ-induced splenomegaly ( p = 0.0665) compared to untreated psoriasis ( Supplementary Figure S7 ).

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showed a trendp = 0.0762so close (0.05 < p ≤ 0.1)

Over the course of the 7-day treatment period, 5% diacerein and placebo application showed a trend towards decreased scaling ( p = 0.0762 and p = 0.0747, respectively), while application of 2.5% and 10% diacerein diminished the scaling scores ( p = 0.0076 and p = 0.0161, respectively) compared to untreated IMQ-induced psoriasis.

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