Metformin, Empagliflozin, and Their Combination Modulate Ex-Vivo Macrophage Inflammatory Gene Expression.

Int J Mol Sci · 2023 · PMC10003317 · PMID 36902218

Europe PMC DOI

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closest p · 1.2× alpha

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boldest claim

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showed a trendp = 0.06so close (0.05 < p ≤ 0.1)

Regarding Clec7a expression, exposures of 10 μM metformin or 10 μM empagliflozin also showed a trend towards increased Clec7a expression ( Figure 6 D) at 24-h (2.33-fold, p = 0.06; 2.23-fold, p = 0.08), respectively.

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did not reach statistical significanceno p-value reported

A similar increase was also observed after 24-h exposure ( Figure 1 E), however this did not reach statistical significance, possibly reflecting the more immediate nature of the TNFα response.

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