Different MAPT haplotypes influence expression of total MAPT in postmortem brain tissue.

Acta Neuropathol Commun · 2023 · PMC10008602 · PMID 36906636

Europe PMC DOI

hedged sentences

0.0670

closest p · 1.3× alpha

0.0670

boldest claim

The sentences

did not reach statistical significanceP = 0.067so close (0.05 < p ≤ 0.1)

The same trend for increased insoluble protein ratios was also observed for insoluble total tau but did not reach statistical significance for the effect of disease ( P = 0.067 ).

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showed a trendno p-value reported

Only 1N4R tau isoform of insoluble tau showed a trend towards increased expression in the H1/H1 haplotype, but this did not reach the level of statistical significance.

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