Mouse mutants in schizophrenia risk genes GRIN2A and AKAP11 show EEG abnormalities in common with schizophrenia patients.

Grin2a (but not Akap11 ) heterozygous mutants exhibited an intermediate phenotype of increased gamma oscillations during REM sleep (Figure S 3 ), although this result did not reach statistical significance (3 months: p = 0.190; 6 months: p = 0.111) We found changes in oscillation power outside of gamma frequencies.

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Similarly, we observed reduced 50 Hz ASSR in both Grin2a KO and Hets at 6 months and a strong trend towards reduced 40 Hz ASSR in Akap11 KO at 3 months (Fig. 5 ).

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