Barely Significant
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DNA methylation patterns associated with breast cancer prognosis that are specific to tumor subtype and menopausal status.

Front Genet · 2023 · PMC10018014 · PMID 36936429

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showed a trendno p-value reported
Moreover, in the same type of cell lines, the knockout of DVL1 showed a trend of increased estradiol levels compared to non-target controls, although it was not statistically significant.

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While the directions of associations were similar, most did not reach statistical significance, potentially due to the smaller sample size of the GEO dataset.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.