Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43.

Area-under-the-curve (AUC) and mobility fraction (m.f.) analyses, indicating the overall proportion of highly mobile proteins within the nucleus, showed a trend for decreased mobility of endogenous fusion proteins relative to their over-expressed forms but these did not reach statistical significance (AUC = 67.80 and 82.61, m.f. = 44.61 and 58.81%, respectively, for -mAvicFP1/GFP [Fig. 3 g]; AUC = 68.12 and 76.95, m.f. = 41.93 and 48.51%, respectively, for -mCherry [Fig. 3 h]).

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