MicroRNA signature and integrative omics analyses define prognostic clusters and key pathways driving prognosis in patients with neuroendocrine neoplasms.

Mol Oncol · 2023 · PMC10061291 · PMID 36795001

Europe PMC DOI

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0.0630

closest p · 1.3× alpha

0.0630

boldest claim

The sentences

showed a trendp = 0.063so close (0.05 < p ≤ 0.1)

Conversely, poor prognosis patients showed a trend towards higher levels of these two miRNAs than NET cell lines (miR‐17‐5p: H727 vs NENs, p = 0.063; BON‐1 vs NENs, p = 0.066; miR‐19a‐3p: H727 vs NENs, p = 0.085; BON‐1 vs NENs, p = 0.088).

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a clear trendno p-value reported

Despite not being statistically significant, miR‐19a‐3p, miR‐20b‐5p and miR‐92a‐3p show a clear trend towards a poorer prognosis with higher miRNA levels.

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a nonsignificant trendno p-value reported

Basal expression levels of miR‐17‐5p and miR‐19a‐3p in NET cell lines were similar to those obtained in the good prognosis cluster of NENs, whereas a nonsignificant trend was observed towards higher miRNA levels in tumour samples of patients of the poor prognosis cluster (Fig.

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