Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.

1 ), a significant increase in sputum CD14 - CD16 - cDCs, and a strong trend ( p = 0.056) for an increase in CD1c + cDC2s, the dominant subset of sputum CD14 - CD16 − cDCs, was associated with human patent infection (Fig. 2D ).

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We found that patent schistosome infection led to more dramatic airway cytokine changes than pre-patent infection, with a clear trend for an increase in airway levels of Ym-1, Relmα and CCL17 (Fig. 4B ).

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