Conversely, the PD-risk factor T408M (also known as T369M, rs75548401) showed a trend toward a faster rate of cognitive decline that did not reach statistical significance, in keeping with a previous study. 43 The mild GD-causing variant N409S (also known as N370S, rs76763715) has shown inconsistent association with cognitive decline in PD.
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Association between the LRP1B and APOE loci and the development of Parkinson's disease dementia.
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