Male-selective effects of oxytocin agonism on alcohol intake: behavioral assessment in socially housed prairie voles and involvement of RAGE.

Differences in alcohol intake approached significance at the 1 h post-treatment time point ( p = 0.08) and were found to be non-specific to alcohol at 2 h post-treatment—both doses of OXT decreased alcohol intake, but 10 mg/kg of OXT increased water intake in males (alcohol: p = 0.02; water: p = 0.04, Fig. 1B ).

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The difference in alcohol intake between males treated with LIT-001 and their male vehicle control counterparts did not reach statistical significance ( p = 0.10); however, significant differences were found between LIT-001-treated males and female controls ( p = 0.01), as well as their LIT-001-treated female counterparts ( p = 0.02; Fig. 5A ).

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