Identification of biomarkers for glycaemic deterioration in type 2 diabetes.

Nat Commun · 2023 · PMC10156700 · PMID 37137910

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nominally significantno p-value reported

Finally, the most consistent risk factor for time to insulin was isoleucine level, which was nominally significant in the discovery cohort (HR = 1.09, 95% CI = 0.96–1.25), a risk factor for incident diabetes in MDC (HR = 1.48, 95% CI = 1.26–1.74) and DESIR (OR = 23.88, 95% CI = 3.13–182.31) as well as prevalent diabetes (OR = 10.94, 95% CI = 3.94,30.32).

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showed a trendno p-value reported

In external validation cohorts, Hcit showed a trend as a risk factor for incident diabetes (HR = 1.05, 95% CI = 0.74–1.48) in MDC.

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