Ketogenic diet enhances the effects of oxycodone in mice.

Sci Rep · 2023 · PMC10170077 · PMID 37160959

Europe PMC DOI

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showed a trendno p-value reported

After dietary intervention, male KD mice showed a significant reduction in oral self-administration compared to Chow, and female KD mice showed a trend reduction as well.

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a strong trendno p-value reported

While both sexes experienced improved analgesic effects during opiate use for pain relief, a KD was only efficacious in reducing opiate consumption in male mice, whereas the females exhibited a strong trend in reduction.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.