COVID-19 convalescent plasma boosts early antibody titer and does not influence the adaptive immune response.

JCI Insight · 2023 · PMC10174456 · PMID 36862515

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showed a trendno p-value reported

A trial in the Netherlands was halted early after high vaccination levels in the population were achieved, but it showed a trend toward a reduction in hospitalizations after receipt of CCP with an effect size consistent with the Argentinian and CSSC-004 trials ( 14 ).

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did not reach statistical significanceno p-value reported

Four recent randomized, controlled trials of CCP in outpatients were evenly split between those showing efficacy ( 12 , 13 ) and those showing no effect ( 15 , 16 ), with a fifth showing potential efficacy that did not reach statistical significance ( 14 ).

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