The MOV10 RNA helicase is a dosage-dependent host restriction factor for LINE1 retrotransposition in mice.

PLoS Genet · 2023 · PMC10174503 · PMID 37126510

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0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

did not reach statistical significancep = 0.10so close (0.05 < p ≤ 0.1)

The litter size of the mice decreased from 5.8 at G0 to 3.8 at G3, but the decrease did not reach statistical significance ( p = 0.10, Fig 5F ).

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a clear trendno p-value reported

There does seem to be a clear trend that there is more retrotransposition in MOV10-/- mice, but given that MOV10 seems to bind to and affect so many transcripts, this modest retrotransposition increase could very well be an indirect effect.

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