Development and testing of a polygenic risk score for breast cancer aggressiveness.

In contrast, the difference in survival between tertiles in the Pathways Study did not reach statistical significance (log-rank chi-squared = 2.4, p = 0.3) (Fig. 6b ).

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Six of 76 SNPs in our final ROR-P PRS had nominally significant associations with ROR-P, though none met significance after Bonferroni correction.

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