KRT5⁺/p63⁺ Stem Cells Undergo Senescence in the Human Lung with Pathological Aging.

Among the aged individuals, those cases with lung pathology presented a higher number of p16 INK4A and p21 CIP positive cells, reaching 3-fold average elevation, although this difference did not reach statistical significance ( Fig. 2C ).

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In the case of proliferation rate, no significant changes in Ki67 positive cells were found, although aged individuals showed a trend of higher Ki67 expression, especially in the case of aged patients with pulmonary diseases ( Fig. 2A-C ).

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