Association between changes in loop diuretic dose and outcomes in acute heart failure.

In our study, patients with loop diuretics prescription at discharge tended to have a lower risk of 30 day all‐cause mortality compared with those without loop diuretics prescription, but the difference did not reach statistical significance (HR 0.41, 95% CI 0.10–1.09, P = 0.07; data not shown in the Results section).

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reported that an increase in loop diuretic doses compared with no change was associated with higher risk of HF death after index visit, whereas a decrease in loop diuretic doses compared with no change showed a trend of lower HF and cardiovascular deaths after index visit in outpatients with chronic HF. 16 Furthermore, novel effective, safe pharmacologic, and established methods to achieve decongestion without inducing end‐organ damage are needed.

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