Notch signaling inactivation by small molecule γ-secretase inhibitors restores the multiciliated cell population in the airway epithelium.

We found that 1 mg/kg LY450139 or 10 mg/kg DAPT lead to a modest, but statistically significant increase in the number of multiciliated cells, whereas 0.1 mg/kg LY450139 showed a trend toward more multiciliated cells that did not reach statistical significance ( Fig. 3, A and B ).

also in 53,322 other papers