Proteomics Methodologies: The Search of Protein Biomarkers Using Microfluidic Systems Coupled to Mass Spectrometry.

Due to the progression conducted in LC, there is a strong trend in recent years to incorporate these techniques for protein separation without affecting their conformational structure, and consequently their biological activity [ 21 ]. 2.1.

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There is still substantial optimization to carry out, although there is a clear trend toward the development of multifunctional chip-ESI-IM-MS interfaces, not just focusing on separation strategies. 5.

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