Combination of Drug Delivery Properties of PAMAM Dendrimers and Cytotoxicity of Platinum(IV) Complexes-A More Selective Anticancer Treatment?

Pharmaceutics · 2023 · PMC10221222 · PMID 37242758

Europe PMC DOI

hedged sentences

0.0750

closest p · 1.5× alpha

0.0750

boldest claim

The sentences

did not reach statistical significancep = 0.075so close (0.05 < p ≤ 0.1)

In addition, concerning the tumor growth curves, the strongest activity was exerted by C12 , although the difference between free cisplatin and C12 did not reach statistical significance in the multiple comparison tests ( p = 0.075).

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showed a trendno p-value reported

In contrast to the cisplatin and G4 PAMAM dendrimer treatment arms, only the anticancer activity of C12 showed a trend towards longer survival ( p -value of 0.0549 in log-rank and 0.05 in Gehan–Breslow–Wilcoxon test) in the direct comparison with the solvent control arm.

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