Prognostic impact of the post-treatment T cell composition and spatial organization in soft tissue sarcoma patients treated with neoadjuvant hyperthermic radio(chemo)therapy.

Front Immunol · 2023 · PMC10228739 · PMID 37261361

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0840

boldest claim

The sentences

a strong trendp=0.06so close (0.05 < p ≤ 0.1)

In the peritumoral area, higher frequencies of CD3 + or CD8 + T cells were linked to significantly longer DFS (p=0.0097), while an increased density of PD-1 + CD8 + T cells showed a strong trend towards a positive impact on DFS (p=0.06) ( Figure 5B ).

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showed a trendp=0.084so close (0.05 < p ≤ 0.1)

A higher ratio of intratumoral to peritumoral CD3 + T cells showed a trend towards a positive impact on DFS (p=0.084), while an increased ratio of CD8 + T cells was associated with significantly better clinical outcome (p=0.014) ( Figures 7D, E ).

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